N*3*-[4,5']BIPYRIMIDINYL-2-YL-4-METHYL-BENZENE-1,3-DIAMINE

Base Information

• Chemical Name: N*3*-[4,5']BIPYRIMIDINYL-2-YL-4-METHYL-BENZENE-1,3-DIAMINE
• CAS No.: 641615-36-3
• Molecular Formula: C15 H14N6
• Molecular Weight: 278.316
• Mol file: 641615-36-3.mol

Synonyms:ZLE0133

Chemical Property of N*3*-[4,5']BIPYRIMIDINYL-2-YL-4-METHYL-BENZENE-1,3-DIAMINE

Chemical Property:

• PSA: 89.61000
• Density: 1.311
• LogP: 3.22200

Purity/Quality:

97% ^*data from raw suppliers

4-METHYL-3-[4-(5-PYRIMIDINYL)PYRIMIDIN-2-YLAMINO]ANILINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N*3*-[4,5']BIPYRIMIDINYL-2-YL-4-METHYL-BENZENE-1,3-DIAMINE

There total 3 articles about N*3*-[4,5']BIPYRIMIDINYL-2-YL-4-METHYL-BENZENE-1,3-DIAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(2-methyl-5-nitrophenyl)-4-(5-pyrimidinyl)-2-pyrimidineamine (641615-35-2) → N1-([4,5'-bipyrimidin]-2-yl)-6-methylbenzene-1,3-diamine (641615-36-3)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 30 ℃; for 18h; under 3040.2 Torr;

Reference yield:

1-(pyrimidin-5-yl)ethan-1-one (10325-70-9) → N1-([4,5'-bipyrimidin]-2-yl)-6-methylbenzene-1,3-diamine (641615-36-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: isopropyl alcohol / 24 h / 100 °C

2.1: sodium hydroxide / isopropyl alcohol / 20 °C

3.1: hydrogenchloride; water / water / 2 h

3.2: pH > 8

With hydrogenchloride; water; sodium hydroxide; In water; isopropyl alcohol;

Reference yield:

(E)-3-(dimethylamino)-1-(pyrimidin-5-yl)prop-2-en-1-one (1232062-67-7) → N1-([4,5'-bipyrimidin]-2-yl)-6-methylbenzene-1,3-diamine (641615-36-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / isopropyl alcohol / 20 °C

2.1: hydrogenchloride; water / water / 2 h

2.2: pH > 8

With hydrogenchloride; water; sodium hydroxide; In water; isopropyl alcohol;

upstream raw materials:

N-(2-methyl-5-nitrophenyl)-4-(5-pyrimidinyl)-2-pyrimidineamine

(E)-3-(dimethylamino)-1-(pyrimidin-5-yl)prop-2-en-1-one

1-(pyrimidin-5-yl)ethan-1-one

Downstream raw materials:

N-[3-(4,5'-bipyrimdine-2-ylamino)-4-methylphenyl]-1-(4-methylpiperazin-1-yl)-2,3-dihydro-1H-indene-5-carboxamide

4-[(S)-3-(t-butoxycarbonylamino)-2-oxopyrrolidin-1-ylmethyl]-3-trifluoromethyl-N-{4-methyl-3-[4-(5-pyrimidinyl)pyrimidin-2-ylamino] phenyl}benzamide

4-[4-(2-fluoroethyl)piperazin-1-ylmethyl]-3-trifluoromethyl-N-{4-methyl-3-[4-(5-pyrimidinyl)pyrimidin-2-ylamino]phenyl}benzamide

N-[3-([4, 5']bipyrimidinyl-2-ylamino)-4-methyl-phenyl]-3-trifluoromethyl-benzamide