BZ-PHE-BOROLEU

Base Information

• Chemical Name: BZ-PHE-BOROLEU
• CAS No.: 1370037-52-7
• Molecular Formula: C22H30ClN3OS
• Molecular Weight: 420.01
• Mol file: 1370037-52-7.mol

Synonyms:COMPOUND 12;BZ-PHE-BOROLEU;GAMMA-SECRETASE INHIBITOR XV;N-METHYL-N′-PHENYL-6-(2,2,3,3-TETRAFLUOROPROPOXY)-1,3,5-TRIAZINE-2,4-DIAMINE;N-[6-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]hexyl]-3-sulfanylpropanamide;1-(5-CYCLOHEXYL-2-OXO-1-PROPYL-3H-1,4-BENZODIAZEPIN-3-YL)-3-[4-(4-PYRIDIN-3-YLPIPERAZIN-1-YL)PHENYL]UREA

Chemical Property of BZ-PHE-BOROLEU

Chemical Property:

• PSA: 92.82000
• LogP: 5.63930

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of BZ-PHE-BOROLEU

There total 4 articles about BZ-PHE-BOROLEU which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.7%

S-3-(6-(6-chloro-1,2,3,4-tetrahydroacridin-9-ylamino)hexylamino)-3-oxopropyl ethanethioate (1370037-59-4) → N-(6-(6-chloro-1,2,3,4-tetrahydroacridin-9-ylamino)hexyl)-3-mercaptopropanami (1370037-52-7)

Guidance literature:

With hydrogenchloride; water; In methanol; at 40 ℃; for 12h; Inert atmosphere;

DOI:10.1021/jm300124p

Reference yield:

N1-(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)hexane-1,6-diamine (681211-37-0) → N-(6-(6-chloro-1,2,3,4-tetrahydroacridin-9-ylamino)hexyl)-3-mercaptopropanami (1370037-52-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 25 °C

1.2: 12 h / 25 °C

2.1: hydrogenchloride; water / methanol / 12 h / 40 °C / Inert atmosphere

With hydrogenchloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;

DOI:10.1021/jm300124p

Reference yield:

1,6-Hexanediamine (124-09-4) → N-(6-(6-chloro-1,2,3,4-tetrahydroacridin-9-ylamino)hexyl)-3-mercaptopropanami (1370037-52-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: pentan-1-ol / 18 h / 180 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 25 °C

2.2: 12 h / 25 °C

3.1: hydrogenchloride; water / methanol / 12 h / 40 °C / Inert atmosphere

With hydrogenchloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane; pentan-1-ol;

DOI:10.1021/jm300124p

upstream raw materials:

N¹-(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)hexane-1,6-diamine

1,6-Hexanediamine

S-3-(6-(6-chloro-1,2,3,4-tetrahydroacridin-9-ylamino)hexylamino)-3-oxopropyl ethanethioate

6,9-dichloro-1,2,3,4-tetrahydroacridine

Refernces