(2R,3R)- 3-hydroxy-2-PyrrolidineMethanol

Base Information

• Chemical Name: (2R,3R)- 3-hydroxy-2-PyrrolidineMethanol
• CAS No.: 198625-17-1
• Molecular Formula: C5 H11 NO2
• Molecular Weight: 117.15
• Mol file: 198625-17-1.mol

Synonyms:(2R,3R)-2-(hydroxymethyl)-3-hydroxypyrrolidine;(2R,3R)-2-(hydroxymethyl)pyrrolidin-3-ol;(2R,3R)-2-Hydroxymethyl-pyrrolidin-3-ol;

Chemical Property of (2R,3R)- 3-hydroxy-2-PyrrolidineMethanol

Chemical Property:

• PSA: 52.49000
• LogP: -0.96970

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3R)- 3-hydroxy-2-PyrrolidineMethanol

There total 23 articles about (2R,3R)- 3-hydroxy-2-PyrrolidineMethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(2R,3R)-1-(Benzyloxycarbonyl)-3-hydroxy-2-(hydroxymethyl)pyrrolidine (133161-12-3) → (R,R)-3-hydroxy-2-hydroxymethylpyrrolidine (198625-17-1,350592-84-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 6h; under 4137.29 Torr;

DOI:10.1039/c5ra01340b

Reference yield:

(R,R)-3-acetoxy-2-hydroxymethylpyrrolidine benzoate (350592-96-0) → (R,R)-3-hydroxy-2-hydroxymethylpyrrolidine (198625-17-1,350592-84-6)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃; for 1h;

DOI:10.1021/jo001736h

Reference yield:

(2R,3R)-2-Hydroxymethyl-1-((S)-1-phenyl-ethyl)-pyrrolidin-3-ol (123098-96-4) → (R,R)-3-hydroxy-2-hydroxymethylpyrrolidine (198625-17-1,350592-84-6)

Guidance literature:

With palladium dihydroxide; hydrogen; In methanol; for 20h;

DOI:10.1021/jo00281a022

upstream raw materials:

(2R,3R)-2-Hydroxymethyl-1-((S)-1-phenyl-ethyl)-pyrrolidin-3-ol

(R,R)-3-acetoxy-2-hydroxymethylpyrrolidine benzoate

(R,R)-4-hydroxy-4-(4,5-dihydro-2-phenyl-4-oxazolyl)-1-butene

(R,R)-4-hydroxy-4-(4,5-dihydro-2-phenyl-4-oxazolyl)-1-butene acetate

Downstream raw materials:

(2R,3R)-N-benzoyl-2-<(benzoyloxy)methyl>-3-(benzoyloxy)pyrrolidine

(2R,3R)-N-benzyl-2-(hydroxymethyl)-3-hydroxypyrrolidine

N-[9-(2-{(2R,3R)-3-Hydroxy-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-pyrrolidin-1-yl}-2-oxo-ethyl)-9H-purin-6-yl]-benzamide

N-{9-[2-((2R,3R)-3-Hydroxy-2-hydroxymethyl-pyrrolidin-1-yl)-2-oxo-ethyl]-9H-purin-6-yl}-benzamide

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