tert-butyl 4-chloro-5,6-dihydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(8H)-carboxylate7(6H)-carboxylic acid

Base Information

Chemical Name:tert-butyl 4-chloro-5,6-dihydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(8H)-carboxylate7(6H)-carboxylic acid
CAS No.:946198-89-6
Molecular Formula:C14H16ClN3O2S
Molecular Weight:325.819
Hs Code.:2934999090
Mol file:946198-89-6.mol

Synonyms:tert-butyl 4-chloro-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7-carboxylate;tert-Butyl 4-chloro-5,6-dihydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(8H)-carboxylate;4-chloro-5,8-dihydro-6H-pyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7-carboxylic acid tert-butyl ester;4-Chloro-5,8-dihydro-6H-9-thia-1,3,7-triaza-fluorene-7-carboxylic acid tert-butyl ester;tert-butyl 4-chloro-5,8-dihydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(6H)-carboxylate;

Suppliers and Price of tert-butyl 4-chloro-5,6-dihydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(8H)-carboxylate7(6H)-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
tert-Butyl4-Chloro-5,6-dihydropyrido[4'',3'':4,5]thieno[2,3-D]pyrimidine-7(8H)-carboxylate
50mg
$ 45.00

Crysdot
tert-Butyl4-chloro-5,6-dihydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(8H)-carboxylate 95+%
1g
$ 846.00

Alichem
tert-Butyl4-chloro-5,6-dihydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(8H)-carboxylate
1g
$ 862.54

Alichem
tert-Butyl4-chloro-5,6-dihydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(8H)-carboxylate
250mg
$ 335.16

AK Scientific
Tert-Butyl4-chloro-5,6-dihydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(8H)-carboxylate
250mg
$ 536.00

Abosyn
Pyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(6H)-carboxylicacid,4-chloro-5,8-dihydro-,1,1-dimethylethylester 95%-98%
1g
$ 855.00

Total 15 raw suppliers

Chemical Property of tert-butyl 4-chloro-5,6-dihydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(8H)-carboxylate7(6H)-carboxylic acid

Chemical Property:

Boiling Point:465.4±45.0 °C(Predicted)
PKA:0.70±0.20(Predicted)
PSA：83.56000
Density:1.377±0.06 g/cm3(Predicted)
LogP:3.57580
Storage Temp.:2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-Chloro-5,6-dihydropyrido[4'',3'':4,5]thieno[2,3-D]pyrimidine-7(8H)-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert-butyl 4-chloro-5,6-dihydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(8H)-carboxylate7(6H)-carboxylic acid

There total 4 articles about tert-butyl 4-chloro-5,6-dihydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(8H)-carboxylate7(6H)-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 874801-60-2
tert-butytert-butyl-4-oxo-3,4,5,6,7,8-hexahydropyrido[4′,3′:4,5]thieno-[2,3-d]pyrimidine-7-carboxylatel-4-oxo-3,4,5,6,7,8-hexahydropyrido[4′,3′:4,5]thieno-[2,3-d]pyrimidine-7-carboxylate

: 946198-89-6
tert-butyl 4-chloro-5,6-dihydropyrido(4’,3’:4,5)thieno(2,3-d)pyrimidine-7(8H)-carboxylate

Guidance literature:: With triethylamine; trichlorophosphate; In sulfolane; at 20 - 70 ℃; for 2.5h;

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 946198-89-6
tert-butyl 4-chloro-5,6-dihydropyrido(4’,3’:4,5)thieno(2,3-d)pyrimidine-7(8H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sulfur; triethylamine / 16 h / 20 °C

2: N,N-dimethyl-formamide / 16 h / 100 °C

3: triethylamine; trichlorophosphate / 3 h / 60 °C

With sulfur; triethylamine; trichlorophosphate; In N,N-dimethyl-formamide; 1: |Gewald Aminoheterocycles Synthesis / 2: |Niementowski Quinazolone Synthesis;
DOI:10.1039/c3md00118k

Reference yield:

: 193537-14-3
2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3,6-dicarboxylic acid 6-tert-butyl ester 3-ethyl ester

: 946198-89-6
tert-butyl 4-chloro-5,6-dihydropyrido(4’,3’:4,5)thieno(2,3-d)pyrimidine-7(8H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 16 h / 100 °C

2: triethylamine; trichlorophosphate / 3 h / 60 °C

With triethylamine; trichlorophosphate; In N,N-dimethyl-formamide; 1: |Niementowski Quinazolone Synthesis;
DOI:10.1039/c3md00118k