7-broMo-5-Methylbenzo[b]thiophene

Base Information

• Chemical Name: 7-broMo-5-Methylbenzo[b]thiophene
• CAS No.: 19076-19-8
• Molecular Formula: C9H7BrS
• Molecular Weight: 227.12088
• Mol file: 19076-19-8.mol

Synonyms:7-broMo-5-Methylbenzo[b]thiophene

Chemical Property of 7-broMo-5-Methylbenzo[b]thiophene

Chemical Property:

• PSA: 28.24000
• LogP: 3.97220

Purity/Quality:

95% ^*data from raw suppliers

7-Bromo-5-methylbenzo[b]thiophene 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-broMo-5-Methylbenzo[b]thiophene

There total 2 articles about 7-broMo-5-Methylbenzo[b]thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

7-bromo-5-methylbenzo[b]thiophene-2-carboxylic acid → 7-bromo-5-methylbenzo[b]thiophene (19076-19-8)

Guidance literature:

With quinoline; copper(l) iodide; at 200 ℃; for 0.5h;

Reference yield:

methyl 7-bromo-5-methylbenzo[b]thiophene-2-carboxylate → 7-bromo-5-methylbenzo[b]thiophene (19076-19-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; water / methanol; tetrahydrofuran / 12 h / 20 °C

2: copper(l) iodide; quinoline / 0.5 h / 200 °C

With quinoline; copper(l) iodide; water; sodium hydroxide; In tetrahydrofuran; methanol;

Reference yield:

7-bromo-5-methylbenzo[b]thiophene (19076-19-8) → 4-(5-cyano-benzo[b]thiophen-7-yl)-2-hydroxybenzoic acid

Guidance literature:

Multi-step reaction with 3 steps

1: 2-Methyl-2-nitropropane; N-hydroxyphthalimide; palladium diacetate / acetonitrile / 48 h / 80 °C / Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / N,N-dimethyl-formamide; water / 0.5 h / 90 °C / Inert atmosphere

3: sodium hydroxide; water / methanol; tetrahydrofuran / 12 h / 20 °C

With N-hydroxyphthalimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 2-Methyl-2-nitropropane; water; palladium diacetate; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile; 2: |Suzuki Coupling;

Refernces