Diethyl 2-acetamido-2-((6-nitro-1H-indol-3-yl)methyl)malonate

Base Information

Chemical Name:Diethyl 2-acetamido-2-((6-nitro-1H-indol-3-yl)methyl)malonate
CAS No.:7355-90-0
Molecular Formula:C₁₈H₂₁N₃O₇
Molecular Weight:391.381
Hs Code.:
NSC Number:67774
DSSTox Substance ID:DTXSID00290282
Wikidata:Q82027909

Synonyms:MLS002693615;7355-90-0;Diethyl 2-acetamido-2-((6-nitro-1H-indol-3-yl)methyl)malonate;HMS3085P16;NSC67774;NCIOpen2_008536;DTXSID00290282;NSC-67774;SMR001559562

Suppliers and Price of Diethyl 2-acetamido-2-((6-nitro-1H-indol-3-yl)methyl)malonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of Diethyl 2-acetamido-2-((6-nitro-1H-indol-3-yl)methyl)malonate

Chemical Property:

Vapor Pressure:4.24E-15mmHg at 25°C
Boiling Point:615.8°Cat760mmHg
Flash Point:326.2°C
Density:1.342g/cm³
XLogP3:2.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:9
Exact Mass:391.13795002
Heavy Atom Count:28
Complexity:601

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(CC1=CNC2=C1C=CC(=C2)[N+](=O)[O-])(C(=O)OCC)NC(=O)C

Technology Process of Diethyl 2-acetamido-2-((6-nitro-1H-indol-3-yl)methyl)malonate

There total 3 articles about Diethyl 2-acetamido-2-((6-nitro-1H-indol-3-yl)methyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6954-87-6
N,N-dimethyl-1-(6-nitro-1H-indol-3-yl)methanamine

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 7355-90-0
diethyl acetylamino<(6-nitroindol)-3-ylmethyl>malonate

Guidance literature:: With sodium hydroxide; toluene;

Reference yield:

: 4769-96-4
6-nitroindole

: 7355-90-0
diethyl acetylamino<(6-nitroindol)-3-ylmethyl>malonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / 0.5 h / 0 °C

1.2: 72 h / 20 °C

1.3: 0 °C / pH 13

2.1: sodium hydroxide / toluene / 110 °C / Inert atmosphere

With acetic acid; sodium hydroxide; In toluene;
DOI:10.1039/c7ob02529g