1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride

Base Information

Chemical Name:1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride
CAS No.:100991-92-2
Molecular Formula:C5H12ClNO3
Molecular Weight:169.61
Hs Code.:2933990090
ChEMBL ID:CHEMBL215137
DSSTox Substance ID:DTXSID301016912
Mol file:100991-92-2.mol

Synonyms:100991-92-2;1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride;(2R,3R,4R)-2-(HYDROXYMETHYL)PYRROLIDINE-3,4-DIOL HYDROCHLORIDE;(2R,3R,4R)-2-(Hydroxymethyl)pyrrolidin-1-ium-3,4-diol;chloride;(2R,3R,4R)-2-(hydroxymethyl)pyrrolidine-3,4-diol;hydrochloride;CHEMBL215137;EU-0100366;1,4-Dideoxy-1,4-imino-D-Arabinitol (hydrochloride);2-Hydroxymethyl-3,4-pyrrolidinediol hydrochloride;SCHEMBL6249396;DTXSID301016912;Tox21_500366;CCG-221670;LP00366;NCGC00093800-01;NCGC00261051-01;PD015243;DAB;2-Hydroxymethyl-3,4-pyrrolidinediol;SR-01000075805;SR-01000075805-1;W-200642;1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride, enzyme inhibitor

Suppliers and Price of 1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride
5mg
$ 359.00

TRC
1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride
250mg
$ 695.00

Sigma-Aldrich
1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride enzyme inhibitor
10mg
$ 599.00

Sigma-Aldrich
1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride enzyme inhibitor
25mg
$ 1330.00

Cayman Chemical
1,4-dideoxy-1,4-imino-D-Arabinitol (hydrochloride) ≥95%
1mg
$ 30.00

Cayman Chemical
1,4-dideoxy-1,4-imino-D-Arabinitol (hydrochloride) ≥95%
25mg
$ 337.00

Cayman Chemical
1,4-dideoxy-1,4-imino-D-Arabinitol (hydrochloride) ≥95%
10mg
$ 240.00

Cayman Chemical
1,4-dideoxy-1,4-imino-D-Arabinitol (hydrochloride) ≥95%
5mg
$ 135.00

Biosynth Carbosynth
1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride
50 mg
$ 367.50

Biosynth Carbosynth
1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride
10 mg
$ 131.30

Total 7 raw suppliers

Chemical Property of 1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride

Chemical Property:

Melting Point:110-112 °C(Solv: ethyl ether (60-29-7); methanol (67-56-1))
PSA：72.72000
LogP:-1.99890
Storage Temp.:2-8°C
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:169.0505709
Heavy Atom Count:10
Complexity:98.2

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(C(C(N1)CO)O)O.Cl
Isomeric SMILES:C1[C@H]([C@@H]([C@H](N1)CO)O)O.Cl
Description 1,4-dideoxy-1,4-imino-D-Arabinitol (DAB) is an inhibitor of glycogen phosphorylase, a key enzyme in glycogenolysis. It inhibits glycogenolysis in isolated liver cells (IC50 = 1.0 μM) and in homogenates of cerebral cortex and cerebellum (IC50s = 463 and 383 nM, respectively). DAB is used to inhibit glycogenolysis, in liver and in brain, in various animal models.
Uses 1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride has been used as an α-glucosidase (GAA) inhibitor.

Technology Process of 1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride

There total 39 articles about 1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 135791-03-6
(2R,3R,4R)-3,4-Dibenzyloxy-2-(benzyloxymethyl)pyrrolidine

: 100991-92-2
(2R,3R,4R)-3,4-dihydroxy-2-hydroxymethylpyrrolidine hydrochloride

Guidance literature:: With hydrogenchloride; 20% palladium hydroxide-activated charcoal; hydrogen; In water; isopropyl alcohol; at 20 ℃; for 48h;
DOI:10.1016/j.carres.2019.107855

Reference yield: 100.0%

: 909801-43-0
2,3,5-tri-O-benzyl-1,4-benzylimino-1,4-dideoxy-D-arabinitol

: 100991-92-2
(2R,3R,4R)-3,4-dihydroxy-2-hydroxymethylpyrrolidine hydrochloride

Guidance literature:: With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In ethanol; water; for 24h; Inert atmosphere;
DOI:10.1002/cmdc.201500407

Reference yield: 97.0%

: (2R,3R,4R)-1-benzyloxycarbonyl-3,4-bis-benzyloxy-2-(hydroxymethyl)pyrrolidine

: 100991-92-2
(2R,3R,4R)-3,4-dihydroxy-2-hydroxymethylpyrrolidine hydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; for 24h; under 3102.89 Torr;
DOI:10.1021/ol061614x