(S)-3-(Methylsulfonyl)pyrrolidine

Base Information

• Chemical Name: (S)-3-(Methylsulfonyl)pyrrolidine
• CAS No.: 290328-57-3
• Molecular Formula: C5H11NO2S
• Molecular Weight: 149.21134
• Hs Code.: 2933990090
• Mol file: 290328-57-3.mol

Synonyms:(S)-3-(Methylsulfonyl)pyr...;

Chemical Property of (S)-3-(Methylsulfonyl)pyrrolidine

Chemical Property:

• Boiling Point: 326.9±31.0 °C(Predicted)
• PKA: 8.51±0.10(Predicted)
• PSA: 54.55000
• Density: 1.23±0.1 g/cm3(Predicted)
• LogP: 0.80250
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%,99%, ^*data from raw suppliers

(S)-3-(Methylsulfonyl)pyrrolidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-3-(Methylsulfonyl)pyrrolidine

There total 2 articles about (S)-3-(Methylsulfonyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

(S)-benzyl 3-(methylsulfonyl)pyrrolidine-1-carboxylate → (S)-3-(methylsulfonyl)pyrrolidine (290328-57-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 50 ℃; for 48h;

Reference yield:

(S)-benzyl 3-(methylthio)pyrrolidine-1-carboxylate → (S)-3-(methylsulfonyl)pyrrolidine (290328-57-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tungstate (VI) dihydrate; dihydrogen peroxide / water; methanol / 1 h / 50 °C / Cooling with ice

2: palladium 10% on activated carbon; hydrogen / methanol / 48 h / 50 °C

With sodium tungstate (VI) dihydrate; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; In methanol; water;

Reference yield:

(S)-3-(methylsulfonyl)pyrrolidine (290328-57-3) → C23H23FN2O5S (1080674-92-5)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol / Reflux

2: toluene / 20 °C

3: sodium hexamethyldisilazane / methanol

With sodium hexamethyldisilazane; In methanol; ethanol; toluene; 1: |Michael Addition;

DOI:10.1016/j.bmcl.2012.10.066

Downstream raw materials:

C₂₃H₂₃FN₂O₅S

Refernces