5-Oxa-1-azabicyclo 4.2.0 oct-2-ene-2-carboxylic acid, 3-(chloroMethyl)-7- (4-Met

Base Information

Chemical Name:5-Oxa-1-azabicyclo 4.2.0 oct-2-ene-2-carboxylic acid, 3-(chloroMethyl)-7- (4-Met
CAS No.:91177-27-4
Molecular Formula:C29 H25 Cl N2 O5
Molecular Weight:516.981
Hs Code.:

Synonyms:5-Oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-(chloromethyl)-7-[(4-methylbenzoyl)amino]-8-oxo-, diphenylmethyl ester, (6R-cis)- (9CI);

Suppliers and Price of 5-Oxa-1-azabicyclo 4.2.0 oct-2-ene-2-carboxylic acid, 3-(chloroMethyl)-7- (4-Met

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 33 raw suppliers

Chemical Property of 5-Oxa-1-azabicyclo 4.2.0 oct-2-ene-2-carboxylic acid, 3-(chloroMethyl)-7- (4-Met

Chemical Property:

PSA：84.94000
LogP:4.44640

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-Oxa-1-azabicyclo 4.2.0 oct-2-ene-2-carboxylic acid, 3-(chloroMethyl)-7- (4-Met

There total 10 articles about 5-Oxa-1-azabicyclo 4.2.0 oct-2-ene-2-carboxylic acid, 3-(chloroMethyl)-7- (4-Met which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₅H₃₁ClN₂O₅S

: 91177-27-4
7-(N-4-methylbenzamide)-3-(chloromethyl)-8-oxo-5-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester

Guidance literature:: C₃₅H₃₁ClN₂O₅S; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 10 ℃; for 2.5h;

With sodium thiosulfate; In dichloromethane; water; at 0 - 10 ℃; for 4h;

Reference yield:

: C₂₉H₂₆Cl₂N₂O₅

: 91177-27-4
7-(N-4-methylbenzamide)-3-(chloromethyl)-8-oxo-5-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester

Guidance literature:: With methanol; at 0 - 5 ℃; for 5h; Reagent/catalyst;

Reference yield:

: 17028-66-9
6β-(4-toluamido)penicillanic acid

: 91177-27-4
7-(N-4-methylbenzamide)-3-(chloromethyl)-8-oxo-5-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine; methanesulfonyl chloride / -5 - 10 °C

2.1: sodium tungstate; dihydrogen peroxide / 0 °C

3.1: chloro-trimethyl-silane; triethylamine / 10 °C

4.1: triphenylphosphine / ethyl acetate / 78 °C

5.1: chlorine; sodium hydrogencarbonate / water; ethyl acetate / 20 - 25 °C

5.2: 25 °C

6.1: pyridine; chlorine / dichloromethane

7.1: diethylamine / -20 °C

With pyridine; sodium tungstate; chloro-trimethyl-silane; dihydrogen peroxide; chlorine; sodium hydrogencarbonate; methanesulfonyl chloride; diethylamine; triethylamine; triphenylphosphine; In dichloromethane; water; ethyl acetate;
DOI:10.1016/j.cclet.2012.01.014