methyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetate

Base Information

• Chemical Name: methyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetate
• CAS No.: 959585-44-5
• Molecular Formula: C12H19BN2O4
• Molecular Weight: 266.105
• Hs Code.: 2934999090
• Mol file: 959585-44-5.mol

Synonyms:1H-Pyrazole-1-acetic acid, 4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-, Methyl ester;Methyl 2-[4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]acetate;

Chemical Property of methyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 377.298°C at 760 mmHg
• Flash Point: 181.984°C
• PSA: 62.58000
• Density: 1.145g/cm³
• LogP: 0.35530
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

1-(Methoxycarbonylmethyl)pyrazole-4-boronicacidpinacolester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetate

There total 1 articles about methyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

pyrazole-4-boronic acid pinacol ester (269410-08-4) + bromoacetic acid methyl ester (96-32-2) → [4-(4,4,5,5-tetramethyl-[1,3]dioxaborolan-2-yl)pyrazol-1-yl]-acetic acid methyl ester (959585-44-5)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 90 ℃;

Reference yield: 51.0%

[4-(4,4,5,5-tetramethyl-[1,3]dioxaborolan-2-yl)pyrazol-1-yl]-acetic acid methyl ester (959585-44-5) + 8-bromo-N-tert-butyl-1-(3,5-dichlorophenyl)-7-methoxy-N-methyl-1,4-dihydrochromeno[4,3-c]pyrazole-3-carboxamide → methyl 2-(4-(3-(tert-butyl(methyl)carbamoyl)-1-(3,5-dichlorophenyl)-7-methoxy-1,4-dihydrochromeno[4,3-c]pyrazol-8-yl)-1H-pyrazol-1-yl)acetate

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; In 1,4-dioxane; water; at 90 ℃; for 1h; Inert atmosphere; Microwave irradiation;

Reference yield: 26.0%

[4-(4,4,5,5-tetramethyl-[1,3]dioxaborolan-2-yl)pyrazol-1-yl]-acetic acid methyl ester (959585-44-5) + 5-bromo-N3-(2,6-dichlorobenzyl)pyrazine-2,3-diamine (1219956-75-8) → (4-{5-amino-6-[(2,6-dichlorobenzyl)amino]pyrazin-2-yl}-1H-pyrazol-1-yl)acetic acid

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,2-dichloro-ethane; at 90 ℃; for 18h; Inert atmosphere;

upstream raw materials:

pyrazole-4-boronic acid pinacol ester

bromoacetic acid methyl ester

Downstream raw materials:

2-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-N-(3-(dimethylamino)propyl)acetamide

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