cis-4-AMino-1-Boc-3-hydro...

Base Information

• Chemical Name: cis-4-AMino-1-Boc-3-hydro...
• CAS No.: 1331777-74-2
• Molecular Formula: C10H20N2O3
• Molecular Weight: 216.277
• Mol file: 1331777-74-2.mol

Synonyms:CIS-4-AMINO-1-BOC-3-HYDROXYPIPERIDINE

Chemical Property of cis-4-AMino-1-Boc-3-hydro...

Chemical Property:

• PSA: 75.79000
• LogP: 0.95360

Purity/Quality:

98%,99%, ^*data from raw suppliers

cis-4-Amino-1-boc-3-hydroxypiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of cis-4-AMino-1-Boc-3-hydro...

There total 32 articles about cis-4-AMino-1-Boc-3-hydro... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(3R*,4R*)-tert-butyl 3-azido-4-hydroxypiperidine-1-carboxylate → rac-(3S,4S)-tert-butyl 4-amino-3-hydroxypiperidine-1-carboxylate (1331777-74-2,443955-98-4)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 16h; under 760.051 Torr;

Reference yield: 99.0%

trans-tert-butyl-4-(benzylamino)-3-hydroxypiperidine-1-carboxylate → rac-(3S,4S)-tert-butyl 4-amino-3-hydroxypiperidine-1-carboxylate (1331777-74-2,443955-98-4)

Guidance literature:

With hydrogen; 10% palladium on activated carbon; In ethanol; for 6h; under 2068.65 Torr;

Reference yield: 94.0%

tert-butyl (3RS,4RS)-4-azido-3-hydroxy-piperidine-1-carboxylate (203503-02-0) → 4-amino-3-hydroxy-piperidine-1-carboxylic acid tert-butyl ester (203503-03-1,1331777-74-2,443955-98-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

upstream raw materials:

tert-butyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate

di-tert-butyl dicarbonate

1,2,3,6-tetrahydropyridine

N-Boc-1,2,3,6-tetrahydropyridine

Downstream raw materials:

(3R,4R)-tert-butyl 3-azido-4-[(diphenylmethylene)amino]piperidine-1-carboxylate

Refernces

• 1、 -. "PYRROLO[2,3-D]PYRIMIDINYL, PYRROLO[2,3-B]PYRAZINYL AND PYR-ROLO[2,3-D]PYRIDINYL ACRYLAMIDES". . . Retrieved 2015/06/17.
• 2、 Lv, Kai,Wu, Jinwei,Wang, Jian,Liu, Mingliang,Wei, Zengquan,Cao, Jue,Sun, Yexin,Guo, Huiyuan. "Synthesis and in vitro antibacterial activity of quinolone/naphthyridone derivatives containing 3-alkoxyimino-4-(methyl)aminopiperidine scaffolds". . p. 1754 - 1759. Retrieved 2013/04/10.