6-AMino-1,3,3-triMethyl-2-oxoindoline

Base Information

• Chemical Name: 6-AMino-1,3,3-triMethyl-2-oxoindoline
• CAS No.: 120791-60-8
• Molecular Formula: C11H14N2O
• Molecular Weight: 190
• Mol file: 120791-60-8.mol

Synonyms:6-AMino-1,3,3-triMethyl-2-oxoindoline;6-AMino-1,3,3-triMethyl-2...

Chemical Property of 6-AMino-1,3,3-triMethyl-2-oxoindoline

Chemical Property:

• Boiling Point: 420.9±45.0 °C(Predicted)
• PKA: 3.65±0.40(Predicted)
• PSA: 46.33000
• Density: 1.140±0.06 g/cm3(Predicted)
• LogP: 2.16900

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Amino-1,3,3-trimethyl-2-oxoindoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-AMino-1,3,3-triMethyl-2-oxoindoline

There total 2 articles about 6-AMino-1,3,3-triMethyl-2-oxoindoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1,3-Dihydro-6-nitro-1,3,3-trimethyl-2H-indol-2-one (120791-59-5) → 6-Amino-1,3-dihydro-1,3,3-trimethyl-2H-indol-2-one (120791-60-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; under 760 Torr; Ambient temperature;

DOI:10.1021/jm00127a015

Reference yield:

1,3-Dihydro-3,3-dimethyl-6-nitro-2H-indol-2-one (100510-64-3) → 6-Amino-1,3-dihydro-1,3,3-trimethyl-2H-indol-2-one (120791-60-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMSO

2: 99 percent / hydrogen / 10 percent Pd/C / methanol / 760 Torr / Ambient temperature

With hydrogen; sodium hydride; palladium on activated charcoal; In methanol;

DOI:10.1021/jm00127a015

Reference yield:

6-Amino-1,3-dihydro-1,3,3-trimethyl-2H-indol-2-one (120791-60-8) → ethyl 3-[2-methyl-3-(trifluoromethyl)benzyl]-2,4-dioxo-1-(1,3,3-trimethyl-2-oxo-2,3-dihydro-1H-indol-6-yl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:

Multi-step reaction with 2 steps

1.1: ethanol / 2 h / Reflux

1.2: 1.25 h / 20 °C / Reflux

2.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 2 h / 60 °C

With potassium carbonate; potassium iodide; In ethanol; N,N-dimethyl-formamide;

upstream raw materials:

1,3-Dihydro-6-nitro-1,3,3-trimethyl-2H-indol-2-one

1,3-Dihydro-3,3-dimethyl-6-nitro-2H-indol-2-one

Refernces