N-[3-[(4aS,7aS)-2-Amino-5,7-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(4aH)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide hydrochloride

Base Information

Chemical Name:N-[3-[(4aS,7aS)-2-Amino-5,7-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(4aH)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide hydrochloride
CAS No.:1262036-49-6
Molecular Formula:C18H16F2N4O2S.HCl
Molecular Weight:426.874
Hs Code.:
Mol file:1262036-49-6.mol

Synonyms:UNII-HW8GJY7V7R;

Suppliers and Price of N-[3-[(4aS,7aS)-2-Amino-5,7-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(4aH)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Tocris
LY2886721Hydrochloride ≥98%(HPLC)
50
$ 905.00

Biosynth Carbosynth
LY 2886721 hydrochloride
50 mg
$ 647.50

Biosynth Carbosynth
LY 2886721 hydrochloride
10 mg
$ 185.00

Axon Medchem
LY2886721hydrochloride 99%
5 mg
$ 115.50

Axon Medchem
LY2886721hydrochloride 99%
25 mg
$ 401.50

AK Scientific
LY-2886721hydrochloride
10mg
$ 299.00

Total 13 raw suppliers

Chemical Property of N-[3-[(4aS,7aS)-2-Amino-5,7-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(4aH)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide hydrochloride

Chemical Property:

PSA：112.40000
LogP:4.02850

Purity/Quality:

99%, ^*data from raw suppliers

LY2886721Hydrochloride ≥98%(HPLC) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-[3-[(4aS,7aS)-2-Amino-5,7-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(4aH)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide hydrochloride

There total 11 articles about N-[3-[(4aS,7aS)-2-Amino-5,7-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(4aH)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1262036-50-9
N-[3-[(4aS,7aS)-2-amino-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide

: 1262036-49-6
N-(3-((4aS,7aS)-2-Amino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; ethanol; dichloromethane; at 22 ℃; for 1h;

Reference yield:

: 1262038-80-1
tert-butyl (4aS,7aS)-7a-(2-fluoro-5-(5-fluoropicolinamido)phenyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-ylcarbamate

: 1262036-49-6
N-(3-((4aS,7aS)-2-Amino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 48h;

Reference yield:

: (3aS,6aS)-6a-(5-bromo-2-fluorophenyl)-1-((R)-1-phenylpropyl)tetrahydro-1H,3H-furo[3,4-c]isoxazole

: 1262036-49-6
N-(3-((4aS,7aS)-2-Amino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: copper(l) iodide; potassium iodide; potassium phosphate; N,N`-dimethylethylenediamine / N,N-dimethyl-formamide / 4 h / 110 °C / Industrial scale

2: zinc(II) chloride; hydrogenchloride; hydrogen / propan-1-ol; water / 17 h / 50 °C / 2585.81 Torr / Autoclave; Industrial scale

3: triethylamine / tetrahydrofuran / 2.5 h / 50 °C / Industrial scale

4: 1,1'-carbonyldiimidazole / tetrahydrofuran / 9 h / 50 °C / Glovebox; Reflux; Industrial scale

5: methanesulfonic acid / methanol / 75 °C

6: water; acetonitrile; ethanol / 3.17 h / 45 - 65 °C / Industrial scale

With hydrogenchloride; potassium phosphate; copper(l) iodide; methanesulfonic acid; hydrogen; triethylamine; 1,1'-carbonyldiimidazole; potassium iodide; zinc(II) chloride; N,N`-dimethylethylenediamine; In tetrahydrofuran; methanol; propan-1-ol; ethanol; water; N,N-dimethyl-formamide; acetonitrile; 4: |Mitsunobu Displacement / 6: |Schotten-Baumann Reaction;
DOI:10.1021/op500327t