RAC-5-(4-FLUOROPHENYL)-2-METHYL-1,3-THIAZOLE-4-CARBOXYLIC ACID

Base Information

• Chemical Name: RAC-5-(4-FLUOROPHENYL)-2-METHYL-1,3-THIAZOLE-4-CARBOXYLIC ACID
• CAS No.: 433283-22-8
• Molecular Formula: C11H8FNO2S
• Molecular Weight: 237.254
• Hs Code.: 2934100090
• Mol file: 433283-22-8.mol

Synonyms:RAC-5-(4-FLUOROPHENYL)-2-METHYL-1,3-THIAZOLE-4-CARBOXYLIC ACID;5-(4-fluorophenyl)-2-Methylthiazole-4-carboxylic acid

Chemical Property of RAC-5-(4-FLUOROPHENYL)-2-METHYL-1,3-THIAZOLE-4-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 376.46°C at 760 mmHg
• PKA: 3.81±0.10(Predicted)
• Flash Point: 181.477°C
• PSA: 78.43000
• Density: 1.392g/cm³
• LogP: 2.95580

Purity/Quality:

98%,99%, ^*data from raw suppliers

rac-5-(4-Fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of RAC-5-(4-FLUOROPHENYL)-2-METHYL-1,3-THIAZOLE-4-CARBOXYLIC ACID

There total 4 articles about RAC-5-(4-FLUOROPHENYL)-2-METHYL-1,3-THIAZOLE-4-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl 5-(4-fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylate (1007873-79-1) → 5-(4-fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acid (433283-22-8)

Guidance literature:

methyl 5-(4-fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylate; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 0.5h;

With hydrogenchloride; In water; at 0 ℃; for 0.25h;

Reference yield:

4-fluorobenzaldehyde (459-57-4) → 5-(4-fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acid (433283-22-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / -78 - 20 °C

2.1: acetonitrile / 20 °C / Molecular sieve

2.2: 4 h / Reflux

3.1: lithium hydroxide; water / tetrahydrofuran; methanol / 20 °C

With potassium tert-butylate; water; lithium hydroxide; In tetrahydrofuran; methanol; acetonitrile;

Reference yield:

methyl 3-chloro-3-(4-fluorophenyl)-2-oxopropanoate (160727-95-7) → 5-(4-fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acid (433283-22-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetonitrile / 20 °C / Molecular sieve

1.2: 4 h / Reflux

2.1: lithium hydroxide; water / tetrahydrofuran; methanol / 20 °C

With water; lithium hydroxide; In tetrahydrofuran; methanol; acetonitrile;

upstream raw materials:

methyl 5-(4-fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylate

4-fluorobenzaldehyde

methyl 3-chloro-3-(4-fluorophenyl)-2-oxopropanoate

Downstream raw materials:

1-(3-((5-bromo-pyrimidin-2-ylamino)-methyl)-3,4-dihydro-1H-isoquinolin-2-yl)-1-(5-(4-fluoro-phenyl)-2-methyl-thiazol-4-yl)-methanone

2-[((2S)-1-{[5-(4-fluorophenyl)-2-methyl-1,3-thiazol-4-yl]carbonyl}-2-piperidinyl)methyl]-7-(trifluoromethyl)imidazo[1,2-a]pyridine

Benzofuran-4-carboxylic acid {(R)-3-[5-(4-fluoro-phenyl)-2-methyl-thiazole-4-carbonyl]-thiazolidin-4-ylmethyl}-amide

(+/-)-(5-((5-chloropyridin-2-ylamino)methyl)-6-azaspiro[2.5]octan-6-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone