2,3,4,5,6,7-hexahydro-4-oxo-2-thioxo-1H-CyclopentapyriMidine-1-acetic acid

Base Information

Chemical Name:2,3,4,5,6,7-hexahydro-4-oxo-2-thioxo-1H-CyclopentapyriMidine-1-acetic acid
CAS No.:1349902-20-0
Molecular Formula:C9H10N2O3S
Molecular Weight:226.256
Hs Code.:
Mol file:1349902-20-0.mol

Synonyms:2,3,4,5,6,7-hexahydro-4-oxo-2-thioxo-1H-CyclopentapyriMidine-1-acetic acid;2-(4-Oxo-2-thioxo-2,3,4,5,6,7-hexahydro-1H-cyclopenta[d]pyrimidin-1-yl)acetic acid

Suppliers and Price of 2,3,4,5,6,7-hexahydro-4-oxo-2-thioxo-1H-CyclopentapyriMidine-1-acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
2-(4-Oxo-2-thioxo-2,3,4,5,6,7-hexahydro-1H-cyclopenta[d]pyrimidin-1-yl)aceticacid 95%+
5g
$ 3611.00

Chemenu
2-(4-Oxo-2-thioxo-2,3,4,5,6,7-hexahydro-1H-cyclopenta[d]pyrimidin-1-yl)aceticacid 95%+
1g
$ 782.00

Total 5 raw suppliers

Chemical Property of 2,3,4,5,6,7-hexahydro-4-oxo-2-thioxo-1H-CyclopentapyriMidine-1-acetic acid

Chemical Property:

PSA：107.18000
LogP:0.47920

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(4-Oxo-2-thioxo-2,3,4,5,6,7-hexahydro-1H-cyclopenta[d]pyrimidin-1-yl)aceticacid 95%+ ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2,3,4,5,6,7-hexahydro-4-oxo-2-thioxo-1H-CyclopentapyriMidine-1-acetic acid

There total 3 articles about 2,3,4,5,6,7-hexahydro-4-oxo-2-thioxo-1H-CyclopentapyriMidine-1-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 540-72-7
sodium thiocyanide

: 6000-44-8
sodium glycinate

: 10472-24-9,265317-94-0
methyl 2-oxocyclopentane-1-carboxylate

: 1349902-20-0
2-(4-oxo-2-thioxo-2,3,4,5,6,7-hexahydro-1H-cyclopenta-[d]-pyrimidin-1-yl) acetic acid

Guidance literature:: sodium glycinate; methyl 2-oxocyclopentane-1-carboxylate; With 1-methyl-pyrrolidin-2-one; at 60 ℃; for 2h; Inert atmosphere;

sodium thiocyanide; With chloro-trimethyl-silane; at 120 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.bmcl.2017.12.052

Reference yield:

: 1349902-19-7
sodium ({2-[(methyloxy)carbonyl]-1-cyclopenten-1-yl}amino)acetate

: 540-72-7
sodium thiocyanide

: 1349902-20-0
2-(4-oxo-2-thioxo-2,3,4,5,6,7-hexahydro-1H-cyclopenta-[d]-pyrimidin-1-yl) acetic acid

Guidance literature:: With chloro-trimethyl-silane; In 1-methyl-pyrrolidin-2-one; water; at 20 - 123 ℃; for 4.5h; Product distribution / selectivity; Inert atmosphere;

Reference yield:

: 10472-24-9,265317-94-0
methyl 2-oxocyclopentane-1-carboxylate

: 1349902-20-0
2-(4-oxo-2-thioxo-2,3,4,5,6,7-hexahydro-1H-cyclopenta-[d]-pyrimidin-1-yl) acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1-methyl-pyrrolidin-2-one / 2.75 h / 60 °C / Inert atmosphere

2: chloro-trimethyl-silane / 1-methyl-pyrrolidin-2-one; water / 4.5 h / 20 - 123 °C / Inert atmosphere

With chloro-trimethyl-silane; In 1-methyl-pyrrolidin-2-one; water;