Norneosildenafil

Base Information

• Chemical Name: Norneosildenafil
• CAS No.: 371959-09-0
• Molecular Formula: C22H29N5O4S
• Molecular Weight: 459.569
• Hs Code.: 29339900
• Mol file: 371959-09-0.mol

Synonyms:Norneosildenafil;1-[[3-(4,7-Dihydro-1-Methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyriMidin-5-yl)-4-ethoxyphenyl]sulfonyl]piperidine;5-[2-Ethoxy-5-(1-piperidinylsulfonyl)phenyl]-1,6-dihydro-1-Methyl-3-propyl-7H-pyrazolo[4,3-d]pyriMidin-7-one

Chemical Property of Norneosildenafil

Chemical Property:

• Vapor Pressure: 9.03E-18mmHg at 25°C
• Melting Point: 190-193°C
• Boiling Point: 669.2°C at 760 mmHg
• PKA: 0.66±0.20(Predicted)
• Flash Point: 358.5°C
• PSA: 118.56000
• Density: 1.39g/cm³
• LogP: 3.86810
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Norneo Sildenafil ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A Sildenafil (S435000) analog

Technology Process of Norneosildenafil

There total 2 articles about Norneosildenafil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperidine (110-89-4) + 5-(5-bromo-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]-pyrimidin-7-one (147676-70-8) → 5-(2-ethoxy-5-(piperidin-1-ylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one (371959-09-0)

Guidance literature:

5-(5-bromo-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]-pyrimidin-7-one; With 1,10-Phenanthroline; potassium pyrosulfite; tetraethylammonium bromide; sodium formate; palladium diacetate; triphenylphosphine; In dimethyl sulfoxide; at 70 ℃; for 3h; Inert atmosphere; Microwave irradiation;

With N-chloro-succinimide; In tetrahydrofuran; at 23 ℃; for 1.5h; Inert atmosphere;

piperidine; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 23 ℃; for 20h; chemoselective reaction; Inert atmosphere;

DOI:10.1021/ol403072r

Reference yield:

5-(2-ethoxy)-phenyl-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidine-7-one (139756-21-1) → 5-(2-ethoxy-5-(piperidin-1-ylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one (371959-09-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium bromide; Oxone / water; acetone / 2 h / 23 °C

2.1: potassium pyrosulfite; sodium formate; palladium diacetate; triphenylphosphine; 1,10-Phenanthroline; tetraethylammonium bromide / dimethyl sulfoxide / 3 h / 70 °C / Inert atmosphere; Microwave irradiation

2.2: 1.5 h / 23 °C / Inert atmosphere

2.3: 20 h / 23 °C / Inert atmosphere

With Oxone; 1,10-Phenanthroline; potassium pyrosulfite; tetraethylammonium bromide; sodium formate; palladium diacetate; triphenylphosphine; potassium bromide; In water; dimethyl sulfoxide; acetone;

DOI:10.1021/ol403072r

upstream raw materials:

5-(2-ethoxy)-phenyl-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidine-7-one

piperidine

5-(5-bromo-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]-pyrimidin-7-one