Acotiamide hydrochloride hydrate

Base Information

• Chemical Name: Acotiamide hydrochloride hydrate
• CAS No.: 773092-05-0
• Molecular Formula: C21H33N4O10ClS
• Molecular Weight: 569.02682
• UNII: NMW7447A9A
• Wikidata: Q27284960
• NCI Thesaurus Code: C72222
• ChEMBL ID: CHEMBL2107308
• Mol file: 773092-05-0.mol

Synonyms:acotiamide;acotiamide hydrochloride;N-(2-(diisopropylamino)ethyl)-2-((2-hydroxy-4,5-dimethoxybenzoyl)amino)-1,3-thiazole-4-carboxamide;N-(N',N'-diisopropylaminoethyl)-(2-(2-hydroxy-4,5-dimethoxybenzoylamino)-1,3-thiazole-4-yl)carboxyamide;YM 443;YM-443;YM443 cpd;Z 338;Z-338

Chemical Property of Acotiamide hydrochloride hydrate

Chemical Property:

• PSA: 175.93000
• LogP: 4.53470
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly) Methanol (Slightly)
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 10
• Exact Mass: 540.2020630
• Heavy Atom Count: 35
• Complexity: 586

Purity/Quality:

99%min ^*data from raw suppliers

AcofideTrihydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)N(CCNC(=O)C1=CSC(=N1)NC(=O)C2=CC(=C(C=C2O)OC)OC)C(C)C.O.O.O.Cl
• Recent ClinicalTrials: A Phase III Trial of Z-338 in Paediatric Patients With Functional Dyspepsia
• Recent EU Clinical Trials: The effect of acotiamide on gastric motility and satiation in healthy volunteers
• Recent NIPH Clinical Trials: A Phase III Trial of Z-338 in Paediatric Patients with Functional Dyspepsia
• Description: In June 2013, the Ministry of Health, Labor and Welfare in Japan approved acotiamide (also referred to as Z-338 and YM443), for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to functional dyspepsia (FD). Acotiamide enhances acetylcholine release from enteric neurons through selective muscarinic acetylcholine receptor M1, M2 antagonism, and inhibition of AChE, thereby enhancing gastric emptying and gastric accommodation. Acotiamide inhibits the acetylcholine-induced Ca2+-activated Cl-current with an IC50 of 1.8 μM in oocytes expressing muscarinic M1 receptors and in oocytes expressing muscarinic M2 receptors, acotiamide inhibited the acetylcholine-induced K+ currents with an IC50 of 10.1 μM. However, studies in conscious dogs, guinea-pig gastric muscle strips and assays with human cholinesterase indicate that acotiamide inhibits AChE with a Ki of 610 nM suggesting that acotiamide stimulates gastric motility mainly by inhibiting AChE activation. In a restraint stress-induced rat model, acotiamide significantly improved delayed gastric emptying and feeding inhibition but did not affect normal gastric emptying or feeding in intact rats. A synthetic route to acotiamide that employs pyridine hydrochloride to selectively cleave a 2-substituted methyl ether from a 2,4,5-trimethoxy benzamide intermediate, as a key step, has been reported.
• Uses: Acofide Trihydrate is a gastrointestinal prokinectic agent used in the treatment of functional malnutrition. A tablet for the treatment of functional dyspepsia.

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 773092-05-0 Ym-443

Send

Send

Metric Ton KG G Pound L ML

Send

Send