Ethyl 2-(2-chlorophenyl)-4-methyl-1,3-thiazole-5-carboxylate

Base Information

Chemical Name:Ethyl 2-(2-chlorophenyl)-4-methyl-1,3-thiazole-5-carboxylate
CAS No.:338982-17-5
Molecular Formula:C13H12ClNO2S
Molecular Weight:282
Hs Code.:2934100090
DSSTox Substance ID:DTXSID70377059
Wikidata:Q72457230
Mol file:338982-17-5.mol

Synonyms:338982-17-5;ethyl 2-(2-chlorophenyl)-4-methyl-1,3-thiazole-5-carboxylate;Ethyl 2-(2-chlorophenyl)-4-methylthiazole-5-carboxylate;5-Thiazolecarboxylic acid, 2-(2-chlorophenyl)-4-methyl-, ethyl ester;DTXSID70377059;MFCD01935973;AKOS005069878;2G-392S;Ethyl2-(2-chlorophenyl)-4-methylthiazole-5-carboxylate

Suppliers and Price of Ethyl 2-(2-chlorophenyl)-4-methyl-1,3-thiazole-5-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
Ethyl 2-(2-chlorophenyl)-4-methyl-1,3-thiazole-5-carboxylate >95%
500mg
$ 98.00

Matrix Scientific
Ethyl 2-(2-chlorophenyl)-4-methyl-1,3-thiazole-5-carboxylate >95%
5g
$ 530.00

Crysdot
Ethyl2-(2-chlorophenyl)-4-methylthiazole-5-carboxylate 95+%
5g
$ 525.00

Chemenu
Ethyl2-(2-chlorophenyl)-4-methyl-1,3-thiazole-5-carboxylate 95%
5g
$ 496.00

Alichem
Ethyl2-(2-chlorophenyl)-4-methylthiazole-5-carboxylate
5g
$ 475.08

AK Scientific
Ethyl2-(2-chlorophenyl)-4-methylthiazole-5-carboxylate
500mg
$ 182.00

Total 8 raw suppliers

Chemical Property of Ethyl 2-(2-chlorophenyl)-4-methyl-1,3-thiazole-5-carboxylate

Chemical Property:

PSA：67.43000
Density:1.280
LogP:3.94860
XLogP3:4.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:281.0277275
Heavy Atom Count:18
Complexity:303

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 2-(2-chlorophenyl)-4-methyl-1,3-thiazole-5-carboxylate >95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(N=C(S1)C2=CC=CC=C2Cl)C

Technology Process of Ethyl 2-(2-chlorophenyl)-4-methyl-1,3-thiazole-5-carboxylate

There total 4 articles about Ethyl 2-(2-chlorophenyl)-4-methyl-1,3-thiazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.5%

: 338982-17-5
ethyl 2-(2-chlorophenyl)-4-methylthiazole-5-carboxylate

Guidance literature:: With sodium carbonate; In ethanol; for 6h; Reflux;

Reference yield: 61.0%

: 638-07-3
ethyl (2-chloroaceto)acetate

: 15717-17-6
2-chlorothiobenzamide

: 338982-17-5
ethyl 2-(2-chlorophenyl)-4-methylthiazole-5-carboxylate

Guidance literature:: In ethanol; for 6h; Reflux;
DOI:10.1016/j.ejmech.2016.02.040

Reference yield:

: 873-32-5
2-Chlorobenzonitrile

: 338982-17-5
ethyl 2-(2-chlorophenyl)-4-methylthiazole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tiolacetic acid; calcium hydride / neat (no solvent) / 3.25 h / 0 - 80 °C / Inert atmosphere

2: pyridine / ethanol / Reflux; Inert atmosphere

With pyridine; calcium hydride; tiolacetic acid; In ethanol;
DOI:10.1016/j.ejmech.2015.04.027