(2S)-2-(4-methylphenyl)pyrrolidine

Base Information

Chemical Name:(2S)-2-(4-methylphenyl)pyrrolidine
CAS No.:1217847-41-0
Molecular Formula:C11H15N
Molecular Weight:161.247
Hs Code.:
DSSTox Substance ID:DTXSID10427461
Nikkaji Number:J2.845.610G
Wikidata:Q82240123

Synonyms:(2S)-2-(4-methylphenyl)pyrrolidine;1217847-41-0;(S)-2-(P-TOLYL)PYRROLIDINE;AC1ODYEV;SCHEMBL6179719;DTXSID10427461;MFCD06762554;AKOS015933122;(S)-2alpha-(4-Methylphenyl)pyrrolidine;BS-50605;CS-0196592

Suppliers and Price of (2S)-2-(4-methylphenyl)pyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of (2S)-2-(4-methylphenyl)pyrrolidine

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:161.120449483
Heavy Atom Count:12
Complexity:136

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C2CCCN2
Isomeric SMILES:CC1=CC=C(C=C1)[C@@H]2CCCN2

Technology Process of (2S)-2-(4-methylphenyl)pyrrolidine

There total 7 articles about (2S)-2-(4-methylphenyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1227798-72-2
C₁₁H₁₅N*ClH

: 1217847-41-0
(S)-2-(4-methylphenyl)pyrrolidine

Guidance literature:: With sodium hydrogencarbonate; In diethyl ether; at 20 ℃; for 0.166667h; optical yield given as %ee;
DOI:10.1039/b925209f

Reference yield:

: tert-butyl (4-oxo-4-(p-tolyl)butyl)carbamate

: 1217847-41-0
(S)-2-(4-methylphenyl)pyrrolidine

: 1227908-77-1
(R)-2-(p-tolyl)pyrrolidine

Guidance literature:: tert-butyl (4-oxo-4-(p-tolyl)butyl)carbamate; With trifluoroacetic acid; In dichloromethane; for 3h; Inert atmosphere; Schlenk technique;

With 1,4-diaza-bicyclo[2.2.2]octane; titanium(IV) isopropylate; bis(1,5-cyclooctadiene)diiridium(I) dichloride; (2R)-1-[(1R)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-[bis[4-(trifluoromethyl)phenyl]phosphino]ferrocene; hydrogen; potassium iodide; In tetrahydrofuran; toluene; at 50 ℃; for 13h; under 38002.6 Torr; Overall yield = 97 percent; Overall yield = 31.2 mg; enantioselective reaction; Autoclave;
DOI:10.1055/s-0037-1611533

Reference yield:

: 22217-77-2
5-(p-tolyl)-3,4-dihydro-2H-pyrrole

: 1217847-41-0
(S)-2-(4-methylphenyl)pyrrolidine

: 1227908-77-1
(R)-2-(p-tolyl)pyrrolidine

Guidance literature:: With diethoxymethylane; diethylzinc; ((2S,2'S)-((2-hydroxy-5-methyl-1,3-phenylene)bis(methylene))bis(pyrrolidine-1,2-diyl))bis(diphenylmethanol); In tetrahydrofuran; toluene; at 4 ℃; for 48h; Overall yield = 92 percent; Overall yield = 69 mg; Inert atmosphere;
DOI:10.1002/adsc.202001043