inositol 1,5-bisphosphate

Base Information

• Chemical Name: inositol 1,5-bisphosphate
• CAS No.: 114418-78-9
• Molecular Formula: C6H14O12P2
• Molecular Weight: 340.117
• Mol file: 114418-78-9.mol

Synonyms:inositol 1,5-bisphosphate

Chemical Property of inositol 1,5-bisphosphate

Chemical Property:

• PSA: 234.06000
• LogP: -3.60060

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of inositol 1,5-bisphosphate

There total 6 articles about inositol 1,5-bisphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2,3,4,6-tetra-O-benzyl-1,5-(di-O-(1R,4R)-1,4-diphenylbutanephospho)myo-inositol → L-myo-inositol 3,5-bisphosphate (114418-78-9,106358-02-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; dichloromethane; at 20 ℃; for 1.5h;

DOI:10.1021/acs.orglett.6b01374

Reference yield:

C6H10O4O2H2(PO3H)2COC6H4 → L-myo-inositol 3,5-bisphosphate (114418-78-9,106358-02-5)

Guidance literature:

With lithium hydroxide; at 80 ℃; for 3h;

DOI:10.1080/07328300701540225

Reference yield:

L-1,2:4,5-di-O-isopropylidene-3-O-benzoyl-6-O-benzyl-myo-inositol (956116-99-7) → L-myo-inositol 3,5-bisphosphate (114418-78-9,106358-02-5)

Guidance literature:

Multi-step reaction with 6 steps

1: TSA / methanol; CH₂Cl₂ / 15 h / 0 °C

2: pyridine / H₂O / 10 h / 90 °C

3: 1H-tetrazole / dimethylformamide; CH₂Cl₂ / 7 h / 20 °C

4: m-CPBA / dimethylformamide; CH₂Cl₂ / 0 - 20 °C

5: acetic acid; H₂; Pd/C / ethanol; methanol / 24 h / 20 °C / 2585.81 Torr

6: LiOH / 3 h / 80 °C

With pyridine; 1H-tetrazole; lithium hydroxide; palladium on activated charcoal; hydrogen; acetic acid; 3-chloro-benzenecarboperoxoic acid; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1080/07328300701540225

upstream raw materials:

L-1,2:4,5-di-O-isopropylidene-3-O-benzoyl-6-O-benzyl-myo-inositol

L-1,2-O-isopropylidene-3-O-benzoyl-6-O-benzyl-myo-inositol

L-1,2-O-isopropylidene-4-O-benzoyl-6-O-benzyl-myo-inositol

benzoyl chloride