Chemical Property of Prenylamine
Chemical Property:
- Vapor Pressure:3.14E-09mmHg at 25°C
- Melting Point:36.5-37.5°
- Refractive Index:1.577
- Boiling Point:476.1°Cat760mmHg
- PKA:pKa 8.74±0.02(40% EtOH,t =25) (Uncertain)
- Flash Point:219.4°C
- PSA：12.03000
- Density:1.023g/cm3
- LogP:5.82030
- Storage Temp.:Refrigerator
- Water Solubility.:50mg/L(37 oC)
- XLogP3:6
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:1
- Rotatable Bond Count:8
- Exact Mass:329.214349865
- Heavy Atom Count:25
- Complexity:316
- Purity/Quality:
-
99% *data from raw suppliers
Prenylamine *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC(CC1=CC=CC=C1)NCCC(C2=CC=CC=C2)C3=CC=CC=C3
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Description
Prenylamine is a calcium channel inhibitor. It inhibits the plasma membrane Ca2+ ATPase (PMCA) in isolated and purified pig cardiac sarcolemma. It binds to a hydrophobic site on calcium-bound calmodulin (CaM) with a Kd value of 0.5 μM and inhibits CaM-activated cAMP phosphodiesterase (PDE) activity when used at concentrations ranging from 10 to 50 μM, an effect that is negatively associated with the concentration of calmodulin. Prenylamine (30 μM) shortens action potential duration and decreases the amplitude of peak calcium currents in single guinea pig ventricular myocytes in the absence and presence of propranolol and phentolamine . Prenylamine (50 mg/kg) decreases epinephrine, serotonin, and dopamine levels in rat brain. It also decreases epinephrine levels in rat heart. It protects anesthetized rats from coronary artery occlusion-induced arrhythmia when administered at a dose of 0.5 mg/kg but increases mortality due to atrioventricular block leading to asystole when administered at a dose of 5 mg/kg.
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Uses
Vasodilator (coronary).
