4-[(4-FLUOROPHENYL)METHYLIDENEAMINO]-5-PYRIDIN-4-YL-2H-1,2,4-TRIAZOLE-3(4H)-THIONE

Base Information

• Chemical Name: 4-[(4-FLUOROPHENYL)METHYLIDENEAMINO]-5-PYRIDIN-4-YL-2H-1,2,4-TRIAZOLE-3(4H)-THIONE
• CAS No.: 488803-79-8
• Molecular Formula: C₁₄H₁₀FN₅S
• Molecular Weight: 299.331
• Mol file: 488803-79-8.mol

Synonyms:4-[(4-FLUOROPHENYL)METHYLIDENEAMINO]-5-PYRIDIN-4-YL-2H-1,2,4-TRIAZOLE-3(4H)-THIONE

Chemical Property of 4-[(4-FLUOROPHENYL)METHYLIDENEAMINO]-5-PYRIDIN-4-YL-2H-1,2,4-TRIAZOLE-3(4H)-THIONE

Chemical Property:

• Melting Point: 245 - 247 °C (water)
• PSA: 90.95000
• LogP: 3.02400

Purity/Quality:

Safty Information:

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Technology Process of 4-[(4-FLUOROPHENYL)METHYLIDENEAMINO]-5-PYRIDIN-4-YL-2H-1,2,4-TRIAZOLE-3(4H)-THIONE

There total 1 articles about 4-[(4-FLUOROPHENYL)METHYLIDENEAMINO]-5-PYRIDIN-4-YL-2H-1,2,4-TRIAZOLE-3(4H)-THIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol (36209-51-5) + 4-fluorobenzaldehyde (459-57-4) → 4-{[(4-fluorophenyl)methylene]amino}-5-pyridin-4-yl-4H-1,2,4-triazole-3-thione (488803-79-8)

Guidance literature:

In ethanol; for 3h; Reflux;

DOI:10.1016/j.ejmech.2009.05.022

Reference yield: 73.0%

1-methyl-piperazine (109-01-3) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + 4-{[(4-fluorophenyl)methylene]amino}-5-pyridin-4-yl-4H-1,2,4-triazole-3-thione (488803-79-8) → 4-{[(4-fluorophenyl)methylene]amino}-5-pyridin-4-yl-2-[(4-methylpiperazin-1-yl)methyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione

Guidance literature:

In water; N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1016/j.ejmech.2009.05.022

upstream raw materials:

4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol

4-fluorobenzaldehyde

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