8-Bromo-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole

Base Information

Chemical Name:8-Bromo-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole
CAS No.:201809-32-7
Molecular Formula:C₁₁H₁₁BrN₂
Molecular Weight:251.126
Hs Code.:
Mol file:201809-32-7.mol

Synonyms:8-Bromo-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole;Pyrazino[1,2-a]indole, 8-bromo-1,2,3,4-tetrahydro-

Suppliers and Price of 8-Bromo-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 8-Bromo-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole

Chemical Property:

Boiling Point:407.9±40.0 °C(Predicted)
PKA:9.99±0.20(Predicted)
Density:1.65±0.1 g/cm3(Predicted)

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 8-Bromo-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole

There total 4 articles about 8-Bromo-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 8-bromo-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one

: 201809-32-7
8-bromo-1,2,3,4-tetrahydropyrazino[1,2-a]indole

: 41838-39-5
1,2,3,4-tetrahydropyrazino<1,2-a>indole

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1002/cmdc.202100707

Reference yield:

: 16732-70-0
ethyl 5-bromoindolecarboxylate

: 201809-32-7
8-bromo-1,2,3,4-tetrahydropyrazino[1,2-a]indole

: 41838-39-5
1,2,3,4-tetrahydropyrazino<1,2-a>indole

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

1.2: 20 °C

2.1: hydrogenchloride / ethyl acetate / 0.5 h / 20 °C

3.1: sodium hydroxide / methanol; water / 3 h / 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; lithium aluminium tetrahydride; sodium hydride; sodium hydroxide; In tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/cmdc.202100707

Reference yield:

: ethyl 5-bromo-1-{2-[(tert-butoxycarbonyl)amino]ethyl}-1H-indole-2-carboxylate

: 201809-32-7
8-bromo-1,2,3,4-tetrahydropyrazino[1,2-a]indole

: 41838-39-5
1,2,3,4-tetrahydropyrazino<1,2-a>indole

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / ethyl acetate / 0.5 h / 20 °C

2: sodium hydroxide / methanol; water / 3 h / 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; lithium aluminium tetrahydride; sodium hydroxide; In tetrahydrofuran; methanol; water; ethyl acetate;
DOI:10.1002/cmdc.202100707