6-BROMO-IMIDAZO[1,2-A]PYRIMIDINE HBR

Base Information

• Chemical Name: 6-BROMO-IMIDAZO[1,2-A]PYRIMIDINE HBR
• CAS No.: 915278-11-4
• Molecular Formula: BrH*C₆H₄BrN₃
• Molecular Weight: 278.934
• Mol file: 915278-11-4.mol

Synonyms:6-BROMO-IMIDAZO[1,2-A]PYRIMIDINE HBR;IMIDAZO[1,2-A]PYRIMIDINE, 6-BROMO-, MONOHYDROBROMIDE;6-broMoiMidazo[1,2-a]pyriMidine hydrogenbroMide

Chemical Property of 6-BROMO-IMIDAZO[1,2-A]PYRIMIDINE HBR

Chemical Property:

• PSA: 30.19000
• LogP: 2.44990

Purity/Quality:

6-BROMOIMIDAZO[1,2-A]PYRIMIDINE MONOHYDROBROMIDE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-BROMO-IMIDAZO[1,2-A]PYRIMIDINE HBR

There total 1 articles about 6-BROMO-IMIDAZO[1,2-A]PYRIMIDINE HBR which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-2-aminopyrimidine (7752-82-1) + Bromoacetaldehyde diethyl acetal (2032-35-1) → 6-bromoimidazo[1,2-a]pyrimidinium hydrobromide (915278-11-4)

Guidance literature:

With hydrogen bromide; In ethanol; water; Heating / reflux;

Reference yield:

6-bromoimidazo[1,2-a]pyrimidinium hydrobromide (915278-11-4) → phenyl(6-phenylimidazo[1,2-a]pyrimidin-3-yl)methanone

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 95 °C

2: toluene / 0.5 h / 20 - 160 °C / Microwave irradiation

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; toluene; 1: Suzuki Coupling;

Reference yield:

6-bromoimidazo[1,2-a]pyrimidinium hydrobromide (915278-11-4) → phenyl(6-phenylimidazo[1,2-a]pyrimidin-3-yl)methanol

Guidance literature:

Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 95 °C

2: toluene / 0.5 h / 20 - 160 °C / Microwave irradiation

3: sodium tetrahydroborate / methanol / 2 h

With sodium tetrahydroborate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; toluene; 1: Suzuki Coupling;

upstream raw materials:

5-bromo-2-aminopyrimidine

Bromoacetaldehyde diethyl acetal

Downstream raw materials:

6-bromoimidazo[1,2-a]pyrimidine

Refernces