2-BENZYL-1,2,3,3A,5,9B-HEXAHYDRO-PYRROLO[3,4-C]QUINOLIN-4-ONE

Base Information

• Chemical Name: 2-BENZYL-1,2,3,3A,5,9B-HEXAHYDRO-PYRROLO[3,4-C]QUINOLIN-4-ONE
• CAS No.: 1017782-21-6
• Molecular Formula: C₁₈H₁₈N₂O
• Molecular Weight: 278.354
• Hs Code.: 2933990090
• Mol file: 1017782-21-6.mol

Synonyms:2-BENZYL-1,2,3,3A,5,9B-HEXAHYDRO-PYRROLO[3,4-C]QUINOLIN-4-ONE;trans-2-Benzyl-1,2,3,3a,5,9b-hexahydro-pyrrolo[3,4-c]quinolin-4-one

Chemical Property of 2-BENZYL-1,2,3,3A,5,9B-HEXAHYDRO-PYRROLO[3,4-C]QUINOLIN-4-ONE

Chemical Property:

• PSA: 35.83000
• LogP: 2.87730

Purity/Quality:

97% ^*data from raw suppliers

trans-2-Benzyl-1,2,3,3a,5,9b-hexahydro-pyrrolo[3,4-c]quinolin-4-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BENZYL-1,2,3,3A,5,9B-HEXAHYDRO-PYRROLO[3,4-C]QUINOLIN-4-ONE

There total 4 articles about 2-BENZYL-1,2,3,3A,5,9B-HEXAHYDRO-PYRROLO[3,4-C]QUINOLIN-4-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(3S,4R)-1-Benzyl-4-(2-nitro-phenyl)-pyrrolidine-3-carboxylic acid ethyl ester → (3aR,9bS)-2-Benzyl-1,2,3,3a,5,9b-hexahydro-pyrrolo[3,4-c]quinolin-4-one (1017782-21-6)

Guidance literature:

(3S,4R)-1-Benzyl-4-(2-nitro-phenyl)-pyrrolidine-3-carboxylic acid ethyl ester; With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; under 760 Torr;

With toluene-4-sulfonic acid; In ethanol; Heating;

DOI:10.1055/s-2003-42425

Reference yield:

(3S,4R)-1-Benzyl-4-(2-nitro-phenyl)-pyrrolidine-3-carboxylic acid ethyl ester → (3aR,9bS)-2-Benzyl-1,2,3,3a,5,9b-hexahydro-pyrrolo[3,4-c]quinolin-4-one (1017782-21-6) + (3R,4S)-4-(2-Amino-phenyl)-1-benzyl-pyrrolidine-3-carboxylic acid ethyl ester

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; under 760 Torr; Title compound not separated from byproducts;

DOI:10.1055/s-2003-42425

Reference yield:

(E)-ethyl 3-(2-nitrophenyl)acrylate (24393-59-7) → (3aR,9bS)-2-Benzyl-1,2,3,3a,5,9b-hexahydro-pyrrolo[3,4-c]quinolin-4-one (1017782-21-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 88 percent / toluene / 8 h / 110 °C

2.1: H₂ / Pd/C / ethanol / 20 °C / 760 Torr

2.2: 92 percent / TsOH / ethanol / Heating

With hydrogen; palladium on activated charcoal; In ethanol; toluene;

DOI:10.1055/s-2003-42425

upstream raw materials:

(E)-ethyl 3-(2-nitrophenyl)acrylate

N-benzylglycine

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