2-Cyano-4-fluoro-6-Methyl-benzoic acid Methyl ester

Base Information

• Chemical Name: 2-Cyano-4-fluoro-6-Methyl-benzoic acid Methyl ester
• CAS No.: 877151-43-4
• Molecular Formula: C10H8FNO2
• Molecular Weight: 193.177
• Mol file: 877151-43-4.mol

Synonyms:2-Cyano-4-fluoro-6-Methyl-benzoic acid Methyl ester;Methyl 2-cyano-4-fluoro-6-methylbenzoate

Chemical Property of 2-Cyano-4-fluoro-6-Methyl-benzoic acid Methyl ester

Chemical Property:

• PSA: 50.09000
• LogP: 1.79238
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-cyano-4-fluoro-6-methylbenzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Cyano-4-fluoro-6-Methyl-benzoic acid Methyl ester

There total 9 articles about 2-Cyano-4-fluoro-6-Methyl-benzoic acid Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-fluoro-2-iodo-6-methyl-benzoic acid methyl ester (877151-07-0) + copper(l) cyanide → 2-cyano-4-fluoro-6-methylbenzoic acid methyl ester (877151-43-4)

Guidance literature:

In N,N-dimethyl-formamide; at 110 ℃; for 5h;

Reference yield: 35.0%

2-bromo-4-fluoro-6-methylbenzoic acid methyl ester (1262396-04-2) + potassium ferrocyanide → 2-cyano-4-fluoro-6-methylbenzoic acid methyl ester (877151-43-4)

Guidance literature:

With palladium diacetate; sodium carbonate; In 1-methyl-pyrrolidin-2-one; at 120 ℃; Inert atmosphere; Sealed tube;

Reference yield:

2-bromo-4-fluoro-6-methylbenzonitrile (916792-09-1) → 2-cyano-4-fluoro-6-methylbenzoic acid methyl ester (877151-43-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sulfuric acid / water / 150 °C

2.1: sodium nitrite; sulfuric acid / water / 1 h / 80 °C

2.2: 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 23 h / 20 °C

4.1: sodium carbonate; palladium diacetate / 1-methyl-pyrrolidin-2-one / 120 °C / Inert atmosphere; Sealed tube

With sulfuric acid; palladium diacetate; sodium carbonate; potassium carbonate; sodium nitrite; In 1-methyl-pyrrolidin-2-one; water; N,N-dimethyl-formamide;

upstream raw materials:

2-bromo-4-fluoro-6-methylbenzonitrile

2-bromo-4-fluoro-6-methylbenzamide

2-bromo-4-fluoro-6-methyl-benzoic acid

2-bromo-4-fluoro-6-methylbenzoic acid methyl ester