8-Bromo-6-chloro-3-methylimidazo[1,2-a]pyrazine

Base Information

• Chemical Name: 8-Bromo-6-chloro-3-methylimidazo[1,2-a]pyrazine
• CAS No.: 84066-11-5
• Molecular Formula: C₇H₅BrClN₃
• Molecular Weight: 246.494
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID90511231
• Wikidata: Q82369944
• Mol file: 84066-11-5.mol

Synonyms:8-Bromo-6-chloro-3-methylimidazo[1,2-a]pyrazine;84066-11-5;SCHEMBL24386978;DTXSID90511231;MFCD22576309;AKOS022172114;BS-17568;CS-0152859;D82695

Chemical Property of 8-Bromo-6-chloro-3-methylimidazo[1,2-a]pyrazine

Chemical Property:

• PSA: 30.19000
• LogP: 2.45360
• Storage Temp.: 2-8°C
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 244.93554
• Heavy Atom Count: 12
• Complexity: 180

Purity/Quality:

99%, ^*data from raw suppliers

8-Bromo-6-chloro-3-methylimidazo[1,2-a]pyrazine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN=C2N1C=C(N=C2Br)Cl

Technology Process of 8-Bromo-6-chloro-3-methylimidazo[1,2-a]pyrazine

There total 4 articles about 8-Bromo-6-chloro-3-methylimidazo[1,2-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

3-methyl-6,8-dichloroimidazo<1,2-a>pyrazine (84066-16-0) → 3-methyl-6-chloro-8-bromoimidazo<1,2-a>pyrazine (84066-11-5)

Guidance literature:

With hydrogen bromide; sodium bromide; In butanone; for 18h; Heating;

DOI:10.1021/jm00357a009

Reference yield:

2-<(2-hydroxy-1-propyl)amino>-3,5-dichloropyrazine (84066-17-1) → 3-methyl-6-chloro-8-bromoimidazo<1,2-a>pyrazine (84066-11-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 41 percent / Et₃N, (CH₃)3N*SO₃ / dimethylsulfoxide / 16 h / Ambient temperature

2: 93 percent / (CF₃CO)2O / trifluoroacetic acid / 5 h / Ambient temperature

3: 67 percent / NaBr, 5 N aq. HBr / butan-2-one / 18 h / Heating

With hydrogen bromide; sulfur trioxide trimethylamine complex; triethylamine; trifluoroacetic anhydride; sodium bromide; In dimethyl sulfoxide; butanone; trifluoroacetic acid;

DOI:10.1021/jm00357a009

Reference yield:

2-<(2-oxo-1-propyl)amino>-3,5-dichloropyrazine (84066-19-3) → 3-methyl-6-chloro-8-bromoimidazo<1,2-a>pyrazine (84066-11-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / (CF₃CO)2O / trifluoroacetic acid / 5 h / Ambient temperature

2: 67 percent / NaBr, 5 N aq. HBr / butan-2-one / 18 h / Heating

With hydrogen bromide; trifluoroacetic anhydride; sodium bromide; In butanone; trifluoroacetic acid;

DOI:10.1021/jm00357a009

upstream raw materials:

3-methyl-6,8-dichloroimidazo<1,2-a>pyrazine

3-bromo-5-chloro-2-aminopyrazine

2-bromopropionaldehyde diethyl acetal

2-<(2-hydroxy-1-propyl)amino>-3,5-dichloropyrazine

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