2-methyl-2,3-dihydro-1H-inden-2-amine hydrochloride

Base Information

• Chemical Name: 2-methyl-2,3-dihydro-1H-inden-2-amine hydrochloride
• CAS No.: 91817-66-2
• Molecular Weight: 0
• European Community (EC) Number: 810-027-7
• Mol file: 91817-66-2.mol

Synonyms:2-methyl-2,3-dihydro-1H-inden-2-amine hydrochloride;91817-66-2;2-METHYL-INDAN-2-YLAMINE HYDROCHLORIDE;2-methyl-1,3-dihydroinden-2-amine;hydrochloride;SCHEMBL1786173;MFCD18432518;AKOS022185740;SB39917;AS-50322;CS-0153763;EN300-124200;O11950;2-METHYL-2,3-DIHYDRO-1H-INDEN-2-AMINE HCL;2-methyl-2,3-dihydro-1H-inden-2-aminehydrochloride;2-Methyl-indan-2-ylamine hydrochloride, AldrichCPR

Chemical Property of 2-methyl-2,3-dihydro-1H-inden-2-amine hydrochloride

Chemical Property:

• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 183.0814771
• Heavy Atom Count: 12
• Complexity: 139

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CC2=CC=CC=C2C1)N.Cl

Technology Process of 2-methyl-2,3-dihydro-1H-inden-2-amine hydrochloride

There total 6 articles about 2-methyl-2,3-dihydro-1H-inden-2-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

2,3-dihydro-2-methyl-1H-indene-2-carboxylic acid (91142-58-4) → (2-methyl-2,3-dihydro-1H-inden-2-yl)amine hydrochloride (91817-66-2)

Guidance literature:

2,3-dihydro-2-methyl-1H-indene-2-carboxylic acid; With sodium azide; chloroformic acid ethyl ester; triethylamine; In water; acetone; at 0 ℃; for 1.68333h;

With hydrogenchloride; In water; Reflux;

Reference yield:

phenylmethyl (2-methyl-2,3-dihydro-1H-inden-2-yl)carbamate (934765-84-1) → (2-methyl-2,3-dihydro-1H-inden-2-yl)amine hydrochloride (91817-66-2)

Guidance literature:

phenylmethyl (2-methyl-2,3-dihydro-1H-inden-2-yl)carbamate; With hydrogen; palladium 10% on activated carbon; In ethanol; water; for 4h; under 2068.65 Torr;

With hydrogenchloride; In ethyl acetate; at -70 ℃;

Reference yield:

2,3-dihydro-2-methyl-1H-inden-1-one (17496-14-9) → (2-methyl-2,3-dihydro-1H-inden-2-yl)amine hydrochloride (91817-66-2)

Guidance literature:

Multi-step reaction with 5 steps

1: diisopropylamine; n-butyllithium / tetrahydrofuran

2: palladium-carbon / acetic acid; conc H₂SO₄

3: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol

4: triethylamine; benzyl alcohol / benzene

5: palladium-carbon / ethyl acetate; ethanol

With n-butyllithium; lithium hydroxide monohydrate; triethylamine; diisopropylamine; benzyl alcohol; palladium-carbon; In tetrahydrofuran; methanol; conc H₂SO₄; ethanol; water; acetic acid; ethyl acetate; benzene;

upstream raw materials:

phenylmethyl (2-methyl-2,3-dihydro-1H-inden-2-yl)carbamate

2,3-dihydro-2-methyl-1H-indene-2-carboxylic acid

2,3-dihydro-2-methyl-1H-inden-1-one

methyl 2-methyl-2,3-dihydro-1H-indene-2-carboxylate

Downstream raw materials:

5-bromo-2-methyl-2,3-dihydro-1H-inden-2-amine