PFK-015

Base Information

Chemical Name:PFK-015
CAS No.:4382-63-2
Molecular Formula:C₁₇H₁₂N₂O
Molecular Weight:260.295
Hs Code.:
Mol file:4382-63-2.mol

Synonyms:PFK-015;1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one;2-Propen-1-one, 1-(4-pyridinyl)-3-(2-quinolinyl)-;1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one PFK15;1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one

Suppliers and Price of PFK-015

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
PFK15
5mg
$ 50.00

Sigma-Aldrich
PFK15 ≥98% (HPLC)
25mg
$ 385.00

Sigma-Aldrich
PFK15 ≥98% (HPLC)
5mg
$ 97.80

DC Chemicals
PFK-015 >98%
100 mg
$ 250.00

DC Chemicals
PFK-015 >98%
250 mg
$ 450.00

Crysdot
PFK-015 98+%
100mg
$ 507.00

Crysdot
PFK-015 98+%
50mg
$ 278.00

Cayman Chemical
PFK15 ≥95%
10mg
$ 88.00

Cayman Chemical
PFK15 ≥95%
5mg
$ 49.00

Cayman Chemical
PFK15 ≥95%
25mg
$ 196.00

Total 22 raw suppliers

Chemical Property of PFK-015

Chemical Property:

Boiling Point:464.4±45.0 °C(Predicted)
PKA:3.11±0.61(Predicted)
PSA：42.85000
Density:1.237±0.06 g/cm3(Predicted)
LogP:3.52590
Storage Temp.:2-8°C
Solubility.:DMSO: soluble10mg/mL, clear

Purity/Quality:

99%, ^*data from raw suppliers

PFK15 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Description PFK15 (4382-63-2) is an inhibitor of the metabolic enzyme 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3).? PFKFB3 is constitutively expressed by neoplastic cells and is required for the high glycolytic rate (Warburg Effect) of these cells. PFK15 inhibits PFKFB3 (IC50?= 207 nM) without inhibiting 96 other kinases.1?PFK15 was able to potently inhibit glucose and F26BP uptake. It induced apoptosis and reduced tumor growth?in vitro?and?in vivo.?PFK15 has been shown to inhibit tumor growth in various cancer models.2,3

Technology Process of PFK-015

There total 2 articles about PFK-015 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.46%