(S)-Tert-butyl 4-methyl-4-(3-methylpiperazin-1-YL)piperidine-1-carboxylate

Base Information

Chemical Name:(S)-Tert-butyl 4-methyl-4-(3-methylpiperazin-1-YL)piperidine-1-carboxylate
CAS No.:306296-78-6
Molecular Formula:C16H31N3O2
Molecular Weight:297.441
Hs Code.:
Mol file:306296-78-6.mol

Synonyms:306296-78-6;(S)-TERT-BUTYL 4-METHYL-4-(3-METHYLPIPERAZIN-1-YL)PIPERIDINE-1-CARBOXYLATE;Tert-butyl (S)-4-methyl-4-(3-methylpiperazin-1-yl)piperidine-1-carboxylate;SCHEMBL3684503;WLNOFRXLATWAAY-ZDUSSCGKSA-N;AMY14985;AKOS015968517;DB-215285;CS-0450797;A846965;t-Butyl 4-Methyl-4-[(3S)-3-methylpiperazin-1-yl]piperidine-1-carboxylate;(S)-TERT-BUTYL4-METHYL-4-(3-METHYLPIPERAZIN-1-YL)PIPERIDINE-1-CARBOXYLATE;tert-butyl 4-methyl-4-[(3S)-3-methylpiperazin-1-yl]piperidine-1-carboxylate

Suppliers and Price of (S)-Tert-butyl 4-methyl-4-(3-methylpiperazin-1-YL)piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)tetrahydro-2H-pyran-4-yl]methanamine AldrichCPR
5mg
$ 201.00

Alichem
(S)-tert-Butyl4-methyl-4-(3-methylpiperazin-1-yl)piperidine-1-carboxylate
1g
$ 1050.00

Alichem
(S)-tert-Butyl4-methyl-4-(3-methylpiperazin-1-yl)piperidine-1-carboxylate
250mg
$ 416.00

Total 4 raw suppliers

Chemical Property of (S)-Tert-butyl 4-methyl-4-(3-methylpiperazin-1-YL)piperidine-1-carboxylate

Chemical Property:

PSA：44.81000
LogP:2.27430
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:297.24162724
Heavy Atom Count:21
Complexity:370

Purity/Quality:

97% ^*data from raw suppliers

[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)tetrahydro-2H-pyran-4-yl]methanamine AldrichCPR ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CN(CCN1)C2(CCN(CC2)C(=O)OC(C)(C)C)C
Isomeric SMILES:C[C@H]1CN(CCN1)C2(CCN(CC2)C(=O)OC(C)(C)C)C

Technology Process of (S)-Tert-butyl 4-methyl-4-(3-methylpiperazin-1-YL)piperidine-1-carboxylate

There total 5 articles about (S)-Tert-butyl 4-methyl-4-(3-methylpiperazin-1-YL)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 716339-53-6
(S)-tert-butyl 4-(4-benzyl-3-methylpiperazin-1-yl)-4-methylpiperidine-1-carboxylate

: 306296-78-6
tert-butyl-4-methyl-4-[(3S)-3-methylpiperazin-1-yl]piperidine-1-carboxylate

Guidance literature:: With hydrogen; acetic acid; In methanol; for 18h; under 3102.97 Torr; Parr bottle;

Reference yield: 43.9%

: (S)-2-chloro-N-(2-chloropropan-2-yl)acetamide

: 343788-69-2
4-amino-4-methyl-piperidine-1-carboxylic acid tert-butyl ester

: 306296-78-6
tert-butyl-4-methyl-4-[(3S)-3-methylpiperazin-1-yl]piperidine-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; Heating;
DOI:10.1039/b707175b

Reference yield:

: 869725-68-8
(S)-tert-butyl 4-(4-benzyl-3-methylpiperazin-1-yl)-4-cyanopiperidine-1-carboxylate

: 306296-78-6
tert-butyl-4-methyl-4-[(3S)-3-methylpiperazin-1-yl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran

2: 20 % Pd(OH)2/C; hydrogen / methanol; acetic acid / 18 h / 3102.97 Torr

With 20 % Pd(OH)2/C; hydrogen; In tetrahydrofuran; methanol; acetic acid;
DOI:10.1021/ml1001536