3-Nitro-6-[2-(triMethylsilyl)ethoxy]pyridine-2-acetonitrile

Base Information

• Chemical Name: 3-Nitro-6-[2-(triMethylsilyl)ethoxy]pyridine-2-acetonitrile
• CAS No.: 361456-00-0
• Molecular Formula: C₁₂H₁₇N₃O₃Si
• Molecular Weight: 279.371
• Mol file: 361456-00-0.mol

Synonyms:3-Nitro-6-[2-(triMethylsilyl)ethoxy]pyridine-2-acetonitrile

Chemical Property of 3-Nitro-6-[2-(triMethylsilyl)ethoxy]pyridine-2-acetonitrile

Chemical Property:

• Melting Point: 74-78°C
• PSA: 91.73000
• LogP: 3.29608

Purity/Quality:

99% ，98% ^*data from raw suppliers

3-Nitro-6-[2-(trimethylsilyl)ethoxy]pyridine-2-acetonitrile 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25-41
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Nitro-6-[2-(triMethylsilyl)ethoxy]pyridine-2-acetonitrile

There total 3 articles about 3-Nitro-6-[2-(triMethylsilyl)ethoxy]pyridine-2-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(4-chlorophenoxy)acetonitrile (3598-13-8) + 5-nitro-2-(2-trimethylsilanylethoxy)pyridine (135900-24-2) → [3-nitro-6-(2-trimethylsilanyl-ethoxy)-pyridin-2-yl]-acetonitrile (361456-00-0)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at -10 ℃; for 3h;

DOI:10.1016/S0960-894X(01)00022-1

Reference yield:

2-chloro-5-nitropyridine (4548-45-2) → [3-nitro-6-(2-trimethylsilanyl-ethoxy)-pyridin-2-yl]-acetonitrile (361456-00-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / t-BuOK / dimethylformamide / 20 °C

2: 87 percent / t-BuOK / tetrahydrofuran / 3 h / -10 °C

With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(01)00022-1

Reference yield:

2-(Trimethylsilyl)ethanol (2916-68-9) → [3-nitro-6-(2-trimethylsilanyl-ethoxy)-pyridin-2-yl]-acetonitrile (361456-00-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / t-BuOK / dimethylformamide / 20 °C

2: 87 percent / t-BuOK / tetrahydrofuran / 3 h / -10 °C

With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(01)00022-1

upstream raw materials:

(4-chlorophenoxy)acetonitrile

5-nitro-2-(2-trimethylsilanylethoxy)pyridine

2-chloro-5-nitropyridine

2-(Trimethylsilyl)ethanol

Downstream raw materials:

3-phenyl-5-(2-trimethylsilanyl-ethoxy)-1H-pyrrolo[3,2-b]pyridine

3-(4-methoxy-phenyl)-5-(2-trimethylsilanyl-ethoxy)-1H-pyrrolo[3,2-b]pyridine

1-benzyl-3-phenyl-5-(2-trimethylsilanyl-ethoxy)-1H-pyrrolo[3,2-b]pyridine

1-benzyl-3-(4-methoxy-phenyl)-5-(2-trimethylsilanyl-ethoxy)-1H-pyrrolo[3,2-b]pyridine

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