Methyl 1,3-dicyano-4,6,6-trimethyl-2-oxocyclohex-3-enecarboxylate

Base Information

• Chemical Name: Methyl 1,3-dicyano-4,6,6-trimethyl-2-oxocyclohex-3-enecarboxylate
• CAS No.: 74528-90-8
• Molecular Formula: C₁₃H₁₄N₂O₃
• Molecular Weight: 0
• Mol file: 74528-90-8.mol

Synonyms:Methyl 1,3-dicyano-4,6,6-trimethyl-2-oxocyclohex-3-enecarboxylate

Chemical Property of Methyl 1,3-dicyano-4,6,6-trimethyl-2-oxocyclohex-3-enecarboxylate

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 1,3-dicyano-4,6,6-trimethyl-2-oxocyclohex-3-enecarboxylate

There total 5 articles about Methyl 1,3-dicyano-4,6,6-trimethyl-2-oxocyclohex-3-enecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-Amino-3-methoxy-2,6,6-tricyano-3,5,5-trimethylcyclohexene (74528-89-5) → Methyl 1,3-Dicyano-2-oxo-4,6,6-trimethyl-3-cyclohexene-1-carboxylate (74528-90-8)

Guidance literature:

With hydrogenchloride; for 1h; Heating;

DOI:10.1055/s-1980-29270

Reference yield: 62.0%

5-amino-4,6-dicyano-3-methoxy-1,8,8-trimethyl-2-azabicyclo<2.2.2>octa-2,5-diene → Methyl 1,3-Dicyano-2-oxo-4,6,6-trimethyl-3-cyclohexene-1-carboxylate (74528-90-8)

Guidance literature:

With hydrogenchloride; In methanol; for 5h; Heating;

DOI:10.3987/COM-98-8347

Reference yield:

isopropylidenemalonodinitrile (13166-10-4) → Methyl 1,3-Dicyano-2-oxo-4,6,6-trimethyl-3-cyclohexene-1-carboxylate (74528-90-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / NaOCH₃ / methanol / 24 h

2: 90 percent / conc. HCl / ethanol / 0.25 h

With hydrogenchloride; sodium methylate; In methanol; ethanol;

DOI:10.1055/s-1980-28998

upstream raw materials:

1-Amino-3-methoxy-2,6,6-tricyano-3,5,5-trimethylcyclohexene

2-amino-4,6,6-trimethylcyclohexa-2,4-diene-1,1,3-tricarbonitrile

isopropylidenemalonodinitrile