Thieno[3,2-d]pyrimidine, 2-chloro-4-(3-nitrophenoxy)-

Base Information

• Chemical Name: Thieno[3,2-d]pyrimidine, 2-chloro-4-(3-nitrophenoxy)-
• CAS No.: 1353553-07-7
• Molecular Formula: C12H6ClN3O3S
• Molecular Weight: 307.717
• Mol file: 1353553-07-7.mol

Synonyms:Thieno[3,2-d]pyrimidine, 2-chloro-4-(3-nitrophenoxy)-;2-chloro-4-(3-nitrophenoxy)thieno[3,2-d]pyrimidine

Chemical Property of Thieno[3,2-d]pyrimidine, 2-chloro-4-(3-nitrophenoxy)-

Chemical Property:

• PSA: 109.07000
• LogP: 4.56840
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-chloro-4-(3-nitrophenoxy)thieno[3,2-d]pyrimidine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Thieno[3,2-d]pyrimidine, 2-chloro-4-(3-nitrophenoxy)-

There total 3 articles about Thieno[3,2-d]pyrimidine, 2-chloro-4-(3-nitrophenoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.7%

2,4-dichlorothieno[3,2-d]pyrimidine (16234-14-3) + meta-nitrophenol (554-84-7) → 2-chloro-4-(3-nitrophenoxy)thieno[3,2-d]pyrimidine (1353553-07-7)

Guidance literature:

With caesium carbonate; In 1,4-dioxane; at 20 ℃; for 4h;

DOI:10.1016/j.ejmech.2020.112511

Reference yield:

Methyl 3-aminothiophene-2-carboxylate (22288-78-4) → 2-chloro-4-(3-nitrophenoxy)thieno[3,2-d]pyrimidine (1353553-07-7)

Guidance literature:

Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 12 h / 190 °C

2: trichlorophosphate / 3 h / 200 °C

3: caesium carbonate / N,N-dimethylsulfoneamide / 1 h / 20 °C

With caesium carbonate; trichlorophosphate; In N,N-dimethylsulfoneamide; N,N-dimethyl-formamide;

Reference yield:

1H-thieno[3,2-d]pyrimidine-2,4-dione (16233-51-5) → 2-chloro-4-(3-nitrophenoxy)thieno[3,2-d]pyrimidine (1353553-07-7)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / 3 h / 200 °C

2: caesium carbonate / N,N-dimethylsulfoneamide / 1 h / 20 °C

With caesium carbonate; trichlorophosphate; In N,N-dimethylsulfoneamide;

upstream raw materials:

2,4-dichlorothieno[3,2-d]pyrimidine

meta-nitrophenol

1H-thieno[3,2-d]pyrimidine-2,4-dione

Methyl 3-aminothiophene-2-carboxylate

Downstream raw materials:

N-(5-(4-methylpiperazin-1-yl)pyridin-2-yl)-4-(3-nitrophenoxy)thieno[3,2-d]pyrimidin-2-amine