cyclopropane-1,1-diyldiMethanaMine

Base Information

• Chemical Name: cyclopropane-1,1-diyldiMethanaMine
• CAS No.: 38932-70-6
• Molecular Formula: C₅H₁₂N₂
• Molecular Weight: 100.164
• Mol file: 38932-70-6.mol

Synonyms:cyclopropane-1,1-diyldiMethanaMine;cyclopropane-1,1-diyldiMethanaMine2HCl

Chemical Property of cyclopropane-1,1-diyldiMethanaMine

Chemical Property:

• PSA: 52.04000
• LogP: 1.08460

Purity/Quality:

Cyclopropane-1,1-diyldimethanaminedihydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of cyclopropane-1,1-diyldiMethanaMine

There total 4 articles about cyclopropane-1,1-diyldiMethanaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-bis(azidomethyl)cyclopropane (136476-39-6) → C-(1-Aminomethyl-cyclopropyl)-methylamine (38932-70-6)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; water; for 15h;

DOI:10.1021/ja00023a031

Reference yield:

[1-(hydroxymethyl)cyclopropyl]methanol (39590-81-3) → C-(1-Aminomethyl-cyclopropyl)-methylamine (38932-70-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / pyridine / 2 h / 0 - 5 °C

2: 93 percent / NaN₃ / dimethylsulfoxide / 16 h / 58 - 65 °C

3: Ph₃P / tetrahydrofuran; H₂O / 15 h

With pyridine; sodium azide; triphenylphosphine; In tetrahydrofuran; water; dimethyl sulfoxide;

DOI:10.1021/ja00023a031

Reference yield:

cyclopropane-1,1-dicarboxylic acid (598-10-7) → C-(1-Aminomethyl-cyclopropyl)-methylamine (38932-70-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 77 percent / BH₃*THF / 15 h / Ambient temperature

2: 76 percent / pyridine / 2 h / 0 - 5 °C

3: 93 percent / NaN₃ / dimethylsulfoxide / 16 h / 58 - 65 °C

4: Ph₃P / tetrahydrofuran; H₂O / 15 h

With pyridine; sodium azide; borane-THF; triphenylphosphine; In tetrahydrofuran; water; dimethyl sulfoxide;

DOI:10.1021/ja00023a031

upstream raw materials:

1,1-bis(azidomethyl)cyclopropane

[1-(hydroxymethyl)cyclopropyl]methanol

cyclopropane-1,1-dicarboxylic acid

cyclopropane-1,1-diylbis(methylene) dimethanesulfonate

Downstream raw materials:

[(1S,2R)-2-(Hydroxy-phenyl-methyl)-1,2-dinitro-spiro[2.2]pent-1-yl]-phenyl-methanol

Refernces