N-((3R,4R)-4-fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidin-3-yl)acrylamide

Base Information

• Chemical Name: N-((3R,4R)-4-fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidin-3-yl)acrylamide
• CAS No.: 1776112-90-3
• Molecular Formula: C18H22FN9O2
• Molecular Weight: 415.42
• Mol file: 1776112-90-3.mol

Synonyms:N-((3R,4R)-4-fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidin-3-yl)acrylamide;PF-06747775;CPI-637

Chemical Property of N-((3R,4R)-4-fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidin-3-yl)acrylamide

Chemical Property:

• PSA: 115.02000
• LogP: 1.20680
• Storage Temp.: room temp

Purity/Quality:

99%, ^*data from raw suppliers

PF06747775 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: PF 06747775 is an orally available inhibitor of the epidermall growth factor receptor (EGFR) mutant form T790M showing antineoplastic activity.

Technology Process of N-((3R,4R)-4-fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidin-3-yl)acrylamide

There total 8 articles about N-((3R,4R)-4-fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidin-3-yl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-fluoro-N-(3-methoxy-1-methyl-1H-pyrazol-4-yl)-9-methyl-9H-purin-6-amine + N-((3R,4R)-4-fluoropyrrolidin-3-yl)-3-(methylsulfonyl)propanamide → PF-06747775 (1776112-90-3)

Guidance literature:

2-fluoro-N-(3-methoxy-1-methyl-1H-pyrazol-4-yl)-9-methyl-9H-purin-6-amine; N-((3R,4R)-4-fluoropyrrolidin-3-yl)-3-(methylsulfonyl)propanamide; With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 100 ℃; for 16h;

With potassium tert-butylate; In tetrahydrofuran; dimethyl sulfoxide; at 20 ℃; for 1h; Reagent/catalyst; Solvent; Temperature;

Reference yield:

C19H26FN9O4S → PF-06747775 (1776112-90-3)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; dimethyl sulfoxide; at 23 ℃; for 2h;

DOI:10.1021/acs.jmedchem.6b01894

Reference yield:

2-fluoro-N-(3-methoxy-1-methyl-1H-pyrazol-4-yl)-9H-purin-6-amine → PF-06747775 (1776112-90-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium phosphate / 2-methyltetrahydrofuran / 23 h / 5 - 15 °C / Large scale

2.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 16 h / 100 °C

2.2: 1 h / 20 °C

With potassium phosphate; N-ethyl-N,N-diisopropylamine; In 2-methyltetrahydrofuran; dimethyl sulfoxide;

upstream raw materials:

6-chloro-2-fluoropurine

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