Cyclo(L-Leu-trans-4-hydroxy-L-Pro)

Base Information

Chemical Name:Cyclo(L-Leu-trans-4-hydroxy-L-Pro)
CAS No.:115006-86-5
Molecular Formula:C11H18N2O3
Molecular Weight:226.276
Hs Code.:
Mol file:115006-86-5.mol

Synonyms:Cyclo(L-Leu-trans-4-hydroxy-L-Pro);3-Isobutyl-8-hydroxyhexahydropyrrolo [1,2-a] pyrazine-1,4-dione;Cyclo(L-leucyl-trans-4-hydroxy-L-proline)

Suppliers and Price of Cyclo(L-Leu-trans-4-hydroxy-L-Pro)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Arctom
Cyclo(L-Leu-trans-4-hydroxy-L-Pro) ≥98%
10mg
$ 332.00

Total 8 raw suppliers

Chemical Property of Cyclo(L-Leu-trans-4-hydroxy-L-Pro)

Chemical Property:

Boiling Point:486.9±45.0 °C(Predicted)
PKA:12.92±0.60(Predicted)
PSA：69.64000
Density:1.24±0.1 g/cm3(Predicted)
LogP:-0.24060

Purity/Quality:

98%Min ^*data from raw suppliers

Cyclo(L-Leu-trans-4-hydroxy-L-Pro) ≥98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Cyclo(L-Leu-trans-4-hydroxy-L-Pro)

There total 1 articles about Cyclo(L-Leu-trans-4-hydroxy-L-Pro) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 115006-86-5
(3S,7R,8aS)-hexahydro-7-hydroxy-3-(2-methylpropyl)pyrrolo[1,2-a]pyrazine-1,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 0 °C

2.1: trifluoroacetic acid / dichloromethane / 3 h

2.2: 16 h / Reflux

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.tetasy.2016.12.002

Reference yield: 70.0%

: 115006-86-5
(3S,7R,8aS)-hexahydro-7-hydroxy-3-(2-methylpropyl)pyrrolo[1,2-a]pyrazine-1,4-dione

: 1222778-67-7
(3S,7R,8aS)-3-isobutyloctahydropyrrolo[1,2-a]pyrazine-7-ol

Guidance literature:: With sodium tetrahydroborate; iodine; In tetrahydrofuran; at 0 ℃; Inert atmosphere; Reflux;
DOI:10.1016/j.tetasy.2016.12.002