3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile

Base Information

Chemical Name:3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile
CAS No.:913830-15-6
Molecular Formula:C14H8N4O
Molecular Weight:248.244
Hs Code.:
Mol file:913830-15-6.mol

Synonyms:3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile

Suppliers and Price of 3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
NS 9283
10mg
$ 452.00

Usbiological
NS 9283
5mg
$ 403.00

TRC
NS9283
5mg
$ 115.00

Tocris
NS9283 ≥99%(HPLC)
10
$ 201.00

Tocris
NS9283 ≥99%(HPLC)
50
$ 844.00

Medical Isotopes, Inc.
NS9283
100 mg
$ 2275.00

DC Chemicals
NS9283 >98%
1 g
$ 1300.00

DC Chemicals
NS9283 >98%
250 mg
$ 600.00

DC Chemicals
NS9283 >98%
100 mg
$ 350.00

Cayman Chemical
NS 9283
10mg
$ 163.00

Total 3 raw suppliers

Chemical Property of 3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile

Chemical Property:

Boiling Point:469.9±55.0 °C(Predicted)
PKA:1.40±0.12(Predicted)
PSA：75.60000
Density:1.37±0.1 g/cm3(Predicted)
LogP:2.67028

Purity/Quality:

≥99% by HPLC ^*data from raw suppliers

NS 9283 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description NS 9283 is a positive allosteric modulator of α4β2 subunit-containing nicotinic acetylcholine receptors (nAChRs) that potentiates ACh-induced currents in HEK293 cells expressing human α4β2 subunit-containing nAChRs (EC50 = 4 μM). In vivo, NS 9283 potentiates ABT-594 analgesic efficacy in rat models of carrageenan-induced thermal hyperalgesia, paw skin incision post-operative pain, and monoiodoacetate-induced osteoarthritis. It reduces nicotine, but not sucrose, self-administration and reinstatement in rats when administered at a dose of 3.5 mg/kg.
Uses NS 9283 is a positive allosteric modulator of α4β2 receptor affecting the potency of acetylcholine (Ach) related events. This has been linked to affect on everyday brain function including cognitive function and pain alleviation.

Technology Process of 3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile

There total 3 articles about 3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: