Tyrphostin B48

Base Information

Chemical Name:Tyrphostin B48
CAS No.:133550-35-3
Molecular Formula:C16H12N2O3
Molecular Weight:280.283
Hs Code.:
European Community (EC) Number:810-936-9
DSSTox Substance ID:DTXSID201018515
Nikkaji Number:J412.915F,J623.663D
Wikidata:Q76304050
NCI Thesaurus Code:C1785
Pharos Ligand ID:S8TGXXVVGSPJ
ChEMBL ID:CHEMBL56731
Mol file:133550-35-3.mol

Synonyms:(E)-isomer of AG 494;AG 494;AG-494;alpha-cyano-(3,4-dihydroxy)-N-phenylcinnamide;tyrphostin AG-494;tyrphostin B48

Suppliers and Price of Tyrphostin B48

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
AG494
1mg
$ 45.00

TCI Chemical
Tyrphostin AG 494 >98.0%(HPLC)(N)
20mg
$ 94.00

TCI Chemical
Tyrphostin AG 494 >98.0%(HPLC)(N)
100mg
$ 282.00

DC Chemicals
AG-494 >98%
250 mg
$ 750.00

DC Chemicals
AG-494 >98%
100 mg
$ 450.00

DC Chemicals
AG-494 >98%
1 g
$ 1500.00

Crysdot
(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenylacrylamide 95+%
250mg
$ 338.00

Crysdot
(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenylacrylamide 95+%
5g
$ 2230.00

Crysdot
(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenylacrylamide 95+%
1g
$ 845.00

ChemScene
AG-494 99.06%
100mg
$ 450.00

Total 20 raw suppliers

Chemical Property of Tyrphostin B48

Chemical Property:

Vapor Pressure:2.26E-14mmHg at 25°C
Melting Point:249 °C(dec.)
Refractive Index:1.736
Boiling Point:586.9 °C at 760 mmHg
Flash Point:308.8 °C
PSA：93.35000
Density:1.416 g/cm³
LogP:2.71648
Storage Temp.:−20°C
Solubility.:DMSO: soluble
XLogP3:2.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:280.08479225
Heavy Atom Count:21
Complexity:446

Purity/Quality:

99%, ^*data from raw suppliers

AG494 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 22-24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)NC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N
Isomeric SMILES:C1=CC=C(C=C1)NC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N
Description Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative, compounds that act as PTK blockers. PTK inhibitors that preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-dependent cell proliferation. AG-494 is an inhibitor of epidermal growth factor receptor kinase with an IC50 value of 1 μM in HT-22 cells.

Technology Process of Tyrphostin B48

There total 2 articles about Tyrphostin B48 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%