3-AMINO-5-BROMO-PYRIDINE-2-CARBONITRILE

Base Information

• Chemical Name: 3-AMINO-5-BROMO-PYRIDINE-2-CARBONITRILE
• CAS No.: 573675-27-1
• Molecular Formula: C6H4BrN3
• Molecular Weight: 198.022
• Hs Code.: 2933399090
• Mol file: 573675-27-1.mol

Synonyms:3-AMINO-5-BROMO-PYRIDINE-2-CARBONITRILE;3-Amino-5-bromopicolinonitrile

Chemical Property of 3-AMINO-5-BROMO-PYRIDINE-2-CARBONITRILE

Chemical Property:

• Boiling Point: 376.5±42.0 °C(Predicted)
• PKA: -1.28±0.10(Predicted)
• PSA: 62.70000
• Density: 1.80±0.1 g/cm3(Predicted)
• LogP: 1.87918
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

3-amino-5-bromopyridine-2-carbonitrile ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-AMINO-5-BROMO-PYRIDINE-2-CARBONITRILE

There total 6 articles about 3-AMINO-5-BROMO-PYRIDINE-2-CARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-bromo-3-nitropyridine-2-carbonitrile (573675-25-9) → 3-amino-5-bromopyridine-2-carbonitrile (573675-27-1)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; at 80 ℃;

DOI:10.1016/j.ejmech.2021.114036

Reference yield: 56.0%

5-bromo-3-nitropyridine-2-carbonitrile (573675-25-9) → 3-amino-5-bromopyridine-2-carbonitrile (573675-27-1) + 3-amino-5-bromopyridine-2-carboxylic acid amide (669066-89-1)

Guidance literature:

With iron; acetic acid; at 20 ℃; for 3h;

DOI:10.1021/acs.jmedchem.8b00613

Reference yield:

2,5-dibromopyridin-3-ylamine (90902-84-4) → 3-amino-5-bromopyridine-2-carbonitrile (573675-27-1)

Guidance literature:

With CuCN; at 150 ℃;

upstream raw materials:

2,5-dibromopyridin-3-ylamine

2,5-dibromo-3-nitro-pyridine

5-bromo-3-nitro-pyridin-2-ylamine

5-bromo-3-nitro-2-pyridone

Downstream raw materials:

7-bromopyrido[3,2-d]pyrimidin-4-ol

5-bromo-3-chloro-pyridine-2-carbonitrile

N-(5-bromo-2-cyanopyridin-3-yl)-4-methoxybenzenesulfonamide

N-(6-(6-cyano-5-(4-methoxyphenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide