2-chloro-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid

Base Information

• Chemical Name: 2-chloro-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid
• CAS No.: 1292287-11-6
• Molecular Formula: C7H4ClN3O2
• Molecular Weight: 197.58
• Mol file: 1292287-11-6.mol

Synonyms:2-chloro-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid

Chemical Property of 2-chloro-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid

Chemical Property:

• PSA: 78.87000
• LogP: 1.30950

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-Chloro-7H-pyrrolo[2,3-D]pyrimidine-4-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-Chloro-7H-pyrrolo[2,3-D]pyrimidine-4-carboxylic Acid is used in preparation of 7H-pyrrolo[2,3-d]pyrimidine and 1H-pyrrolo[3,2-c]pyridine derivatives as herbicidal compounds.

Technology Process of 2-chloro-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid

There total 2 articles about 2-chloro-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

4-amino-2-chloro-5-(2-ethoxyethenyl)-6-methoxycarbonyl-pyrimidine (1292287-12-7) → 2-chloro-4-methoxycarbonyl-7H-pyrrolo[2,3-d]pyrimidine (1292287-10-5) + 4-carboxy-2-chloro-7H-pyrrolo[2,3-d]pyrimidine (1292287-11-6)

Guidance literature:

With hydrogenchloride; for 3h; Reflux;

Reference yield:

6-Amino-2-chloro-5-iodopyrimidine-4-carboxylic acid methyl ester (1136962-02-1) → 2-chloro-4-methoxycarbonyl-7H-pyrrolo[2,3-d]pyrimidine (1292287-10-5) + 4-carboxy-2-chloro-7H-pyrrolo[2,3-d]pyrimidine (1292287-11-6)

Guidance literature:

Multi-step reaction with 2 steps

1: bis(tri-t-butylphosphine)palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.33 h / 160 °C / Microwave irradiation

2: hydrogenchloride / 3 h / Reflux

With hydrogenchloride; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In N,N-dimethyl-formamide;

upstream raw materials:

6-Amino-2-chloro-5-iodopyrimidine-4-carboxylic acid methyl ester

4-amino-2-chloro-5-(2-ethoxyethenyl)-6-methoxycarbonyl-pyrimidine

Refernces