CYCLO(-PRO-THR)

Base Information

• Chemical Name: CYCLO(-PRO-THR)
• CAS No.: 227777-31-3
• Molecular Formula: C₉H₁₄N₂O₃
• Molecular Weight: 198.222
• Mol file: 227777-31-3.mol

Synonyms:CYCLO(-PRO-THR)

Chemical Property of CYCLO(-PRO-THR)

Chemical Property:

• PSA: 69.64000
• LogP: -0.87670
• Storage Temp.: -15°C

Purity/Quality:

98.5% ^*data from raw suppliers

Cyclo(-Pro-Thr) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Cyclo(-Pro-Thr) is a diketopiperazine cylclodipeptide inducing the blood-?like, metallic bitter taste sensation isolated from roasted cocoa nibs.

Technology Process of CYCLO(-PRO-THR)

There total 5 articles about CYCLO(-PRO-THR) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

Boc-threonyl-proline methyl ester (94790-38-2) → cis-cyclo(Pro-Thr) (227777-31-3)

Guidance literature:

In water; at 130 ℃; for 4h;

DOI:10.1016/j.tetlet.2009.12.134

Reference yield:

→ 3-(1-hydroxyethyl)hexahydropyrrolo[1,2-a]pyrazin-1,4-dione (227777-31-3)

Guidance literature:

In water; at 130 ℃; for 4h; Autoclave;

Reference yield:

→ 3-(1-hydroxyethyl)hexahydropyrrolo[1,2-a]pyrazin-1,4-dione (227777-31-3)

Guidance literature:

In water; at 130 ℃; for 4h; Autoclave;

upstream raw materials:

Boc-threonyl-proline methyl ester