8-[(R)-2-azido-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-benzyloxy-4H-benzo[1,4]oxazin-3-one

Base Information

Chemical Name:8-[(R)-2-azido-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-benzyloxy-4H-benzo[1,4]oxazin-3-one
CAS No.:1092407-76-5
Molecular Formula:C₂₃H₃₀N₄O₄Si
Molecular Weight:454.601
Hs Code.:

Synonyms:8-[(R)-2-azido-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-benzyloxy-4H-benzo[1,4]oxazin-3-one

Suppliers and Price of 8-[(R)-2-azido-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-benzyloxy-4H-benzo[1,4]oxazin-3-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 8-[(R)-2-azido-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-benzyloxy-4H-benzo[1,4]oxazin-3-one

Chemical Property:

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 8-[(R)-2-azido-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-benzyloxy-4H-benzo[1,4]oxazin-3-one

There total 13 articles about 8-[(R)-2-azido-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-benzyloxy-4H-benzo[1,4]oxazin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1092407-75-4
5-benzyloxy-8-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-2-chloro-ethyl]-4H-benzo[1,4]oxazin-3-one

: 1092407-76-5
8-[(R)-2-azido-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-benzyloxy-4H-benzo[1,4]oxazin-3-one

Guidance literature:: With sodium azide; potassium iodide; In N,N-dimethyl-formamide; at 120 ℃; for 72h;

Reference yield:

: C₃₀H₃₇NO₇SSi

: 1092407-76-5
8-[(R)-2-azido-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-benzyloxy-4H-benzo[1,4]oxazin-3-one

Guidance literature:: With sodium azide; sodium iodide; In dimethyl sulfoxide; at 65 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.bmc.2016.04.028

Reference yield:

: (R)-5-(benzyloxy)-8-(1,2-dihydroxyethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one

: 1092407-76-5
8-[(R)-2-azido-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-benzyloxy-4H-benzo[1,4]oxazin-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; di(n-butyl)tin oxide / acetonitrile; tetrahydrofuran / 16 h / 20 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere

3: sodium azide; sodium iodide / dimethyl sulfoxide / 24 h / 65 °C / Inert atmosphere

With 1H-imidazole; sodium azide; di(n-butyl)tin oxide; triethylamine; sodium iodide; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2016.04.028