7-hydrazinyl-3,4-dihydro-1(2H)-Isoquinolinone

Base Information

• Chemical Name: 7-hydrazinyl-3,4-dihydro-1(2H)-Isoquinolinone
• CAS No.: 897374-26-4
• Molecular Formula: C₉H₁₁N₃O
• Molecular Weight: 177.206
• Mol file: 897374-26-4.mol

Synonyms:7-hydrazinyl-3,4-dihydro-1(2H)-Isoquinolinone;7-hydrazinyl-3,4-dihydroisoquinolin-1(2H)-one

Chemical Property of 7-hydrazinyl-3,4-dihydro-1(2H)-Isoquinolinone

Chemical Property:

• PSA: 70.64000
• LogP: 1.04180

Purity/Quality:

95+% ^*data from raw suppliers

7-hydrazinyl-3,4-dihydro-1(2H)-Isoquinolinone 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-hydrazinyl-3,4-dihydro-1(2H)-Isoquinolinone

There total 5 articles about 7-hydrazinyl-3,4-dihydro-1(2H)-Isoquinolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-amino-3,4-dihydroisoquinoline-1(2H)-one (66491-03-0) → 7-hydrazino-3,4-dihydro-2H-isoquinolin-1-one (897374-26-4)

Guidance literature:

7-amino-3,4-dihydroisoquinoline-1(2H)-one; With hydrogenchloride; sodium nitrite; In water; at 5 ℃; for 0.5h;

With hydrogenchloride; tin(ll) chloride; In water; at 0 ℃; for 2h;

Reference yield:

phenethylamine (64-04-0) → 7-hydrazino-3,4-dihydro-2H-isoquinolin-1-one (897374-26-4)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium carbonate / ethyl acetate; water / 2 h / 0 - 20 °C

2: polyphosphoric acid / 2.5 h / 140 - 160 °C

3: sulfuric acid; nitric acid / 2 h / Cooling with ice

4: hydrogen; palladium 10% on activated carbon / methanol / 20 °C / 2068.65 Torr

5: tin(II) chloride dihdyrate; sodium nitrite; hydrogenchloride / water / 2 h / 0 - 5 °C

With hydrogenchloride; tin(II) chloride dihdyrate; sulfuric acid; palladium 10% on activated carbon; hydrogen; nitric acid; sodium carbonate; sodium nitrite; In methanol; water; ethyl acetate;

Reference yield:

ethyl-N-(2-phenethyl)carbamate (6970-83-8) → 7-hydrazino-3,4-dihydro-2H-isoquinolin-1-one (897374-26-4)

Guidance literature:

Multi-step reaction with 4 steps

1: polyphosphoric acid / 2.5 h / 140 - 160 °C

2: sulfuric acid; nitric acid / 2 h / Cooling with ice

3: hydrogen; palladium 10% on activated carbon / methanol / 20 °C / 2068.65 Torr

4: tin(II) chloride dihdyrate; sodium nitrite; hydrogenchloride / water / 2 h / 0 - 5 °C

With hydrogenchloride; tin(II) chloride dihdyrate; sulfuric acid; palladium 10% on activated carbon; hydrogen; nitric acid; sodium nitrite; In methanol; water;

upstream raw materials:

7-amino-3,4-dihydroisoquinoline-1(2H)-one

phenethylamine

ethyl-N-(2-phenethyl)carbamate

3,4-dihydroisoquinolin-1(2H)-one

Refernces

• 1、 -. "KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES". Page/Page column 48. . Retrieved 2008/06/13.