3-(4-Bromophenyl)-5-methylisoxazole-4-carboxaldehyde

Base Information

• Chemical Name: 3-(4-Bromophenyl)-5-methylisoxazole-4-carboxaldehyde
• CAS No.: 1119449-35-2
• Molecular Formula: C₁₁H₈BrNO₂
• Molecular Weight: 266.094
• Hs Code.: 2934999090
• Mol file: 1119449-35-2.mol

Synonyms:3-(4-Bromophenyl)-5-methylisoxazole-4-carboxaldehyde

Chemical Property of 3-(4-Bromophenyl)-5-methylisoxazole-4-carboxaldehyde

Chemical Property:

• Melting Point: 102-107 °C
• PSA: 43.10000
• LogP: 3.22500
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

3-(4-Bromophenyl)-5-methylisoxazole-4-carboxaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-Bromophenyl)-5-methylisoxazole-4-carboxaldehyde

There total 4 articles about 3-(4-Bromophenyl)-5-methylisoxazole-4-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-benzaldehyde (1122-91-4) → 3-(p-bromophenyl)-5-methylisoxazole-4-carbaldehyde (1119449-35-2)

Guidance literature:

Multi-step reaction with 5 steps

1: hydroxylamine hydrochloride; sodium acetate / ethanol; tetrahydrofuran; water / 72 h / 20 °C / Inert atmosphere

2: N-chloro-succinimide; pyridine / chloroform / 5 h / 40 °C / Inert atmosphere

3: sodium / ethanol / 3 h / 20 °C / Inert atmosphere

4: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

5: pyridinium chlorochromate; magnesium sulfate / dichloromethane / 2 h / Sealed tube; Inert atmosphere

With pyridine; N-chloro-succinimide; lithium aluminium tetrahydride; hydroxylamine hydrochloride; sodium acetate; sodium; magnesium sulfate; pyridinium chlorochromate; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water;

DOI:10.1016/j.bmc.2017.04.008

Reference yield:

4-bromobenzaldehyde oxime (25062-46-8,40979-16-6,34158-73-1) → 3-(p-bromophenyl)-5-methylisoxazole-4-carbaldehyde (1119449-35-2)

Guidance literature:

Multi-step reaction with 4 steps

1: N-chloro-succinimide; pyridine / chloroform / 5 h / 40 °C / Inert atmosphere

2: sodium / ethanol / 3 h / 20 °C / Inert atmosphere

3: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: pyridinium chlorochromate; magnesium sulfate / dichloromethane / 2 h / Sealed tube; Inert atmosphere

With pyridine; N-chloro-succinimide; lithium aluminium tetrahydride; sodium; magnesium sulfate; pyridinium chlorochromate; In tetrahydrofuran; ethanol; dichloromethane; chloroform;

DOI:10.1016/j.bmc.2017.04.008

Reference yield:

3-(p-bromophenyl)-5-methylisoxazole-4-carboxylic acid ethyl ester (954230-26-3) → 3-(p-bromophenyl)-5-methylisoxazole-4-carbaldehyde (1119449-35-2)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: pyridinium chlorochromate; magnesium sulfate / dichloromethane / 2 h / Sealed tube; Inert atmosphere

With lithium aluminium tetrahydride; magnesium sulfate; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmc.2017.04.008

upstream raw materials:

4-bromo-benzaldehyde

4-bromobenzaldehyde oxime

4-bromo-N-hydroxybenzenecarboximidoyl chloride

3-(p-bromophenyl)-5-methylisoxazole-4-carboxylic acid ethyl ester

Refernces