methyl(S)-1-((S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

Base Information

• Chemical Name: methyl(S)-1-((S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate
• CAS No.: 1292836-05-5
• Molecular Formula: C14H21BrN4O3
• Molecular Weight: 373.25
• Mol file: 1292836-05-5.mol

Synonyms:methyl(S)-1-((S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate;N-[(1S)-1-[[(2S)-2-(5-Bromo-1H-imidazol-2-yl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]carbamic acid methyl ester

Chemical Property of methyl(S)-1-((S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

Chemical Property:

• Boiling Point: 609.8±55.0 °C(Predicted)
• PKA: 11.13±0.10(Predicted)
• PSA: 87.32000
• Density: 1.443±0.06 g/cm3(Predicted)
• LogP: 2.54510

Purity/Quality:

99% Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl(S)-1-((S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

There total 16 articles about methyl(S)-1-((S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(S)-5-bromo-2-(pyrrolidin-2-yl)-1H-imidazole hydrochloride (1258234-18-2) + N-methoxycarbonyl-L-valine (111398-44-8,74761-42-5) → methyl ((S)-1-((S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate (1292836-05-5)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;

Reference yield: 43.2%

C7H10BrN3 + N-methoxycarbonyl-L-valine (111398-44-8,74761-42-5) → methyl ((S)-1-((S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate (1292836-05-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

(S)-2-(4-bromo-1H-imidazol-2-yl)pyrrolidine (1258253-82-5) + N-methoxycarbonyl-L-valine (111398-44-8,74761-42-5) → methyl ((S)-1-((S)-2-(4-bromo-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate (1292836-05-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at -15 ℃; Inert atmosphere;

upstream raw materials:

N-(tert-butoxycarbonyl)-L-prolinol

Boc-L-Pro-H

(S)-5-bromo-2-(pyrrolidin-2-yl)-1H-imidazole hydrochloride

N-methoxycarbonyl-L-valine

Downstream raw materials:

C₃₈H₃₃ClF₂N₆O₄S

C₅₂H₅₄F₂N₁₀O₇S

C₄₂H₅₂FN₉O₇

dimethyl((2S,2’S)-((2S,2’S)-2,2’-(5,5’-((S)-6-(2-cyclopropylthiazol-5-yl)-1-fluoro-6H-benzo[5,6][1,3]oxazino[3,4-a]indole-3,10-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3methyl-1oxobutane-2,1-diyl))dicarbamate

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