1-Bromo-4-[(2-methylpropane)sulfinyl]benzene

Base Information

• Chemical Name: 1-Bromo-4-[(2-methylpropane)sulfinyl]benzene
• CAS No.: 363136-59-8
• Molecular Formula: C10H13BrOS
• Molecular Weight: 261.17862
• Hs Code.: 2930909090
• Mol file: 363136-59-8.mol

Synonyms:1-Bromo-4-(isopropylsulfinyl)benzene;1-Bromo-4-[(2-methylpropane)sulfinyl]benzene

Chemical Property of 1-Bromo-4-[(2-methylpropane)sulfinyl]benzene

Chemical Property:

• PSA: 36.28000
• LogP: 3.83080
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-Bromo-4-(isopropylsulfinyl)benzene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Bromo-4-(isopropylsulfinyl)benzene is a useful chemical for the preparation of geminally substituted cyanoethylpyrazolopyridones as janus kinase inhibitors for the treatment of rheumatoid arthritis, asthma, COPD, and cancer.

Technology Process of 1-Bromo-4-[(2-methylpropane)sulfinyl]benzene

There total 2 articles about 1-Bromo-4-[(2-methylpropane)sulfinyl]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(1R,2S,5R)-menthyl (S)-p-bromobenzene sulfinate (873586-66-4) → (R)-p-bromophenyl isopropyl sulfoxide (363136-59-8,1129287-54-2)

Guidance literature:

In tetrahydrofuran; benzene; at 5 ℃; for 1.5h;

DOI:10.1021/jo010334m

Reference yield:

4-bromobenzenesulfonyl chloride (98-58-8) → (R)-p-bromophenyl isopropyl sulfoxide (363136-59-8,1129287-54-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 57 percent / triethylamine; trimethyl phosphite / CH₂Cl₂ / 3 h / Heating

2: 83 percent / tetrahydrofuran; benzene / 1.5 h / 5 °C

With triethylamine; phosphorous acid trimethyl ester; In tetrahydrofuran; dichloromethane; benzene;

DOI:10.1021/jo010334m

Reference yield: 42.0%

(R)-p-bromophenyl isopropyl sulfoxide (363136-59-8,1129287-54-2) → (S)-cyclohexyl isopropyl sulfoxide

Guidance literature:

In tetrahydrofuran; at -30 ℃; for 1.5h;

DOI:10.1021/jo010334m

upstream raw materials:

(1R,2S,5R)-menthyl (S)-p-bromobenzene sulfinate

4-bromobenzenesulfonyl chloride

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