iperazineacetic acid, 4-[(4- chlorophenyl)phenylMethyl]-

Base Information

• Chemical Name: iperazineacetic acid, 4-[(4- chlorophenyl)phenylMethyl]-
• CAS No.: 113740-61-7
• Molecular Formula: C₁₉H₂₁ClN₂O₂
• Molecular Weight: 344.841
• Mol file: 113740-61-7.mol

Synonyms:iperazineacetic acid, 4-[(4- chlorophenyl)phenylMethyl]-

Chemical Property of iperazineacetic acid, 4-[(4- chlorophenyl)phenylMethyl]-

Chemical Property:

• Boiling Point: 489.2±45.0 °C(Predicted)
• PKA: 4.24±0.10(Predicted)
• PSA: 43.78000
• Density: 1.254±0.06 g/cm3(Predicted)
• LogP: 3.00740

Purity/Quality:

98%min ^*data from raw suppliers

Cetirizine impurity B ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of iperazineacetic acid, 4-[(4- chlorophenyl)phenylMethyl]-

There total 2 articles about iperazineacetic acid, 4-[(4- chlorophenyl)phenylMethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)acetate (19178-83-7) → -2-[4-[(4-chorophenyl)phenylmethyl]piperazin-1-yl]acetic acid (113740-61-7)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 70 ℃; for 4h;

DOI:10.1016/j.bmcl.2017.07.047

Reference yield:

N-(4-chlorobenzhydryl)piperazine (303-26-4) → -2-[4-[(4-chorophenyl)phenylmethyl]piperazin-1-yl]acetic acid (113740-61-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / acetone / 24 h / Reflux

2: sodium hydroxide / ethanol; water / 4 h / 70 °C

With sodium hydrogencarbonate; sodium hydroxide; In ethanol; water; acetone;

DOI:10.1016/j.bmcl.2017.07.047

upstream raw materials:

ethyl 2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)acetate

N-(4-chlorobenzhydryl)piperazine

Refernces