3-(p-Tolyl)-2H-azirine-2-carboxamide

Base Information

• Chemical Name: 3-(p-Tolyl)-2H-azirine-2-carboxamide
• CAS No.: 28883-95-6
• Molecular Formula: C10H10N2O
• Molecular Weight: 174.202
• Hs Code.: 2933990090
• Mol file: 28883-95-6.mol

Synonyms:3-(p-Tolyl)-2H-azirine-2-carboxamide

Chemical Property of 3-(p-Tolyl)-2H-azirine-2-carboxamide

Chemical Property:

• PSA: 56.44000
• LogP: 1.23690

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(p-Tolyl)-2H-azirine-2-carboxamide

There total 3 articles about 3-(p-Tolyl)-2H-azirine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-(4-methylphenyl)-1,2-oxazol-5-amine (28883-91-2) → 3-(p-tolyl)-2H-azirine-2-carboxamide (28883-95-6)

Guidance literature:

With Hoveyda-Grubbs catalyst second generation; In ethanol; at 20 ℃; Inert atmosphere; Schlenk technique; Irradiation;

DOI:10.1021/acs.orglett.8b00971

Reference yield:

p-tolueneacetonitrile (7391-28-8) → 3-(p-tolyl)-2H-azirine-2-carboxamide (28883-95-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; sodium acetate / methanol / 20 °C / Inert atmosphere

2: Hoveyda-Grubbs catalyst second generation / ethanol / 20 °C / Inert atmosphere; Schlenk technique; Irradiation

With Hoveyda-Grubbs catalyst second generation; hydroxylamine hydrochloride; sodium acetate; In methanol; ethanol;

DOI:10.1021/acs.orglett.8b00971

Reference yield:

→ 3-(p-tolyl)-2H-azirine-2-carboxamide (28883-95-6)

Guidance literature:

5-Amino-3-p-tolylisooxazol (II), Ae., UV-Belichtung;

DOI:10.1039/j39700001825

upstream raw materials:

p-tolueneacetonitrile

3-(4-methylphenyl)-1,2-oxazol-5-amine

Refernces

• 1、 Ge, Yun,Sun, Wangbin,Pei, Bingbing,Ding, Jia,Jiang, Yaojia,Loh, Teck-Peng. "Hoveyda-Grubbs II Catalyst: A Useful Catalyst for One-Pot Visible-Light-Promoted Ring Contraction and Olefin Metathesis Reactions". . p. 2774 - 2777. Retrieved 2018/05/22.