4-(Difluoromethoxy)-3-ethoxybenzoic acid

Base Information

Chemical Name:4-(Difluoromethoxy)-3-ethoxybenzoic acid
CAS No.:162401-63-0
Molecular Formula:C10H10F2O4
Molecular Weight:232.184
Hs Code.:
DSSTox Substance ID:DTXSID001276250
Mol file:162401-63-0.mol

Synonyms:4-(difluoromethoxy)-3-ethoxybenzoic acid;162401-63-0;4-Difluoromethoxy-3-ethoxy-benzoic acid;MFCD04967203;SCHEMBL7371299;FPNSIXUGULJPGQ-UHFFFAOYSA-N;DTXSID001276250;STK292804;AKOS000103130;4-(difluoromethoxy)-3-ethoxybenzoicacid;4-(Difluoromethoxy)-3-ethoxy-benzoic acid;CS-0221777;EN300-09995;Z56989644

Suppliers and Price of 4-(Difluoromethoxy)-3-ethoxybenzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
4-Difluoromethoxy-3-ethoxy-benzoic acid
1g
$ 378.00

Crysdot
4-(Difluoromethoxy)-3-ethoxybenzoicacid 97%
1g
$ 356.00

AK Scientific
4-Difluoromethoxy-3-ethoxy-benzoicacid
1g
$ 560.00

Total 3 raw suppliers

Chemical Property of 4-(Difluoromethoxy)-3-ethoxybenzoic acid

Chemical Property:

PSA：55.76000
LogP:2.38490
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:232.05471512
Heavy Atom Count:16
Complexity:235

Purity/Quality:

98%min ^*data from raw suppliers

4-Difluoromethoxy-3-ethoxy-benzoic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC1=C(C=CC(=C1)C(=O)O)OC(F)F

Technology Process of 4-(Difluoromethoxy)-3-ethoxybenzoic acid

There total 3 articles about 4-(Difluoromethoxy)-3-ethoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: methyl 4-(difluoromethoxy)-3-ethoxybenzoate

: 162401-63-0
4-(difluoromethoxy)-3-ethoxybenzoic acid

Guidance literature:: With water; sodium hydroxide; In ethanol; at 60 ℃; for 13h;

Reference yield:

: 1159429-52-3
3-hydroxy-4-(difluoromethoxy)-benzoic acid methyl ester

: 162401-63-0
4-(difluoromethoxy)-3-ethoxybenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C / Sealed tube

2: water; sodium hydroxide / ethanol / 13 h / 60 °C

With water; potassium carbonate; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;