Technology Process of (2S)-2-AMINO-2-(6-METHOXY(3-PYRIDYL))ETHAN-1-OL
There total 6 articles about (2S)-2-AMINO-2-(6-METHOXY(3-PYRIDYL))ETHAN-1-OL which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium 10% on activated carbon;
for 1h;
under 760.051 Torr;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: n-butyllithium / tetrahydrofuran / -78 - 20 °C / Inert atmosphere
1.2: 60 °C / Cooling with ice
2.1: AD mix-β / water; tert-butyl alcohol / 6 h / 0 °C
2.2: 0 °C
3.1: pyridine / dichloromethane / 0 - 20 °C
4.1: potassium carbonate / methanol / 0 - 20 °C
5.1: sodium azide; lithium perchlorate / acetonitrile / 4 h / 60 °C
6.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1 h / 760.05 Torr
With
pyridine; n-butyllithium; sodium azide; AD mix-β; hydrogen; lithium perchlorate; potassium carbonate;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; acetonitrile; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: AD mix-β / water; tert-butyl alcohol / 6 h / 0 °C
1.2: 0 °C
2.1: pyridine / dichloromethane / 0 - 20 °C
3.1: potassium carbonate / methanol / 0 - 20 °C
4.1: sodium azide; lithium perchlorate / acetonitrile / 4 h / 60 °C
5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1 h / 760.05 Torr
With
pyridine; sodium azide; AD mix-β; hydrogen; lithium perchlorate; potassium carbonate;
palladium 10% on activated carbon;
In
methanol; dichloromethane; water; ethyl acetate; acetonitrile; tert-butyl alcohol;
